Size-dependent accumulation of particles in lysosomes modulates dendritic cell function through impaired antigen degradation.

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作者： Emilie,Seydoux ^[1] ; Barbara,Rothen-Rutishauser ^[2] ; Izabela M,Nita ^[3] ; Sandor,Balog ^[4] ; Amiq,Gazdhar ^[3] ; Philip A,Stumbles ^[5] ; Alke,Petri-Fink ^[6] ; Fabian,Blank ^[3] ; Christophe,von Garnier ^[3]

作者单位： Department of Respiratory Medicine, Inselspital, Bern University Hospital, Department of Clinical Research, University of Bern, Switzerland ; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland. ^[1] Department of Respiratory Medicine, Inselspital, Bern University Hospital, Department of Clinical Research, University of Bern, Switzerland ; Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland. ^[2] Department of Respiratory Medicine, Inselspital, Bern University Hospital, Department of Clinical Research, University of Bern, Switzerland. ^[3] Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland. ^[4] School of Veterinary and Life Sciences, Molecular and Biomedical Sciences, Murdoch University, Perth, WA, Australia ; Telethon Kids Institute, Perth, WA, Australia. ^[5] Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland ; Department of Chemistry, University of Fribourg, Fribourg, Switzerland. ^[6]

关键词 CD4+ T-cells immune modulation mouse dendritic cells nanoparticles polystyrene particles