Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1.
第一作者:
Sang Hyeon,Yeon
第一单位:
College of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, Korea.
作者:
医学主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);抗病毒药(Antiviral Agents);细胞, 培养的(Cells, Cultured);色酮类(Chromones);DEAD-box RNA解旋酶类(DEAD-box RNA Helicases);二聚作用(Dimerization);酶激活(Enzyme Activation);酶抑制剂(Enzyme Inhibitors);HEK293细胞(HEK293 Cells);人类(Humans);干扰素诱导剂(Interferon Inducers);干扰素调节因子3(Interferon Regulatory Factor-3);干扰素β(Interferon-beta);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);吗啉类(Morpholines);磷酸肌醇3-激酶(Phosphatidylinositol 3-Kinase);磷酰化(Phosphorylation);聚肌胞苷酸(Poly I-C);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);RNA干扰(RNA Interference);RNA, 小分子干扰(RNA, Small Interfering);呼吸病毒感染(Respirovirus Infections);仙台病毒(Sendai virus);信号传导(Signal Transduction)
DOI
10.1111/imm.12373
PMID
25158146
发布时间
2021-10-21
- 浏览49
Immunology
312-20页
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