换一批Short-term exposure of nontumorigenic human bronchial epithelial cells to carcinogenic chromium(VI) compromises their respiratory capacity and alters their bioenergetic signature.
第一作者：
Joana F,Cerveira
第一单位：
Unidade de Química-Física Molecular and Departamento de Ciências da Vida, Universidade de Coimbra, 3000-456 Coimbra, Portugal ; Centro de Biología Molecular "Severo Ochoa", CIBERER, Instituto de Investigación Hospital 12 de Octubre, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
作者：
关键词
2,4-DNP, 2,4-dinitrophenol2-DG, 2-deoxyglucoseAerobic glycolysisCellular bioenergetic indexCellular energy statusCellular respirationChromate lung cancerCr(III), trivalent chromiumCr(IV), tetravalent chromiumCr(V), pentavalent chromiumCr(VI), hexavalent chromiumDCF, 2′,7′-dichlorofluoresceinEDTA, ethylenediaminetetracetic acidETC, mitochondrial electron transport chainGAPDH, glyceraldehyde-3-phosphate dehydrogenaseIARC, International Agency for Research on CancerOCR, oxygen consumption rateOXPHOS, oxidative phosphorylationPBS, phosphate-buffered salinePI, propidium iodideROS, reactive oxygen speciesTCA, tricarboxylic acidWarburg effectβ-F1-ATPase, catalytic subunit (subunit β) of the mitochondrial H+-ATP synthase
DOI
10.1016/j.fob.2014.06.006
PMID
25161867
发布时间
2021-10-21
- 浏览4
FEBS open bio
594-601页
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