The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres.

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作者： R,Gref ^[1] ; A,Domb ^[2] ; P,Quellec ^[1] ; T,Blunk ^[3] ; R H,Müller ^[4] ; J M,Verbavatz ^[5] ; R,Langer ^[6]

作者单位： Laboratoire de Chimie-Physique Macromoléculaire, URA CNRS 494, ENSIC, 1, Rue Grandville, BP 451, 54001 Nancy Cedex, France. ^[1] Department of Pharmaceutical Chemistry, Hebrew University, 91120 Jerusalem, Israel. ^[2] Department of Pharmaceutics and Biopharmaceutics, Christian-Albrechts-University Kiel, Gutenbergstr, 76-78, 24118 Kiel, Germany. ^[3] Department of Pharmaceutics, Biopharmaceutics and Biotechnology, Free University of Berlin, Kelchstr, 31, 12169 Berlin, Germany. ^[4] Service de Biologie Cellulaire, CEA Saclay, 91191 Gif sur Yvette, France. ^[5] Department of Chemical Engineering, MIT, E25-342, 45 Carlton St., Cambridge, MA 02139, USA. ^[6]

关键词 Biodegradable polymers Hydrophilic coating Intravenous drug administration Long-circulating nanoparticles Polyethylene glycol Reduced liver accumulation

DOI 10.1016/0169-409X(95)00026-4

PMID 25170183

发布时间 2024-05-07

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