Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice.-论文-万方医学网

作者： Dalila,Mango ^[1] ; Alessandra,Bonito-Oliva ^[2] ; Ada,Ledonne ^[1] ; Loredana,Cappellacci ^[3] ; Riccardo,Petrelli ^[3] ; Robert,Nisticò ^[4] ; Nicola,Berretta ^[5] ; Gilberto,Fisone ^[2] ; Nicola Biagio,Mercuri ^[6]

作者单位： IRCCS Fondazione Santa Lucia, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. ^[1] Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden. ^[2] School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Italy. ^[3] IRCCS Fondazione Santa Lucia, Rome, Italy; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy. ^[4] IRCCS Fondazione Santa Lucia, Rome, Italy. ^[5] IRCCS Fondazione Santa Lucia, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: mercurin@med.uniroma2.it. ^[6]

主题词动作电位(Action Potentials);年龄因素(Age Factors);动物(Animals);抗震颤麻痹药(Antiparkinson Agents);纹状体(Corpus Striatum);疾病模型, 动物(Disease Models, Animal);多巴胺(Dopamine);运动障碍, 药物性(Dyskinesia, Drug-Induced);酶抑制剂(Enzyme Inhibitors);抑制性突触后电位(Inhibitory Postsynaptic Potentials);左旋多巴(Levodopa);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);运动活动(Motor Activity);神经元(Neurons);帕金森病(Parkinson Disease);受体, 腺苷A1(Receptor, Adenosine A1);受体, 多巴胺D1(Receptors, Dopamine D1);黄嘌呤类(Xanthines)

DOI 10.1016/j.expneurol.2014.08.022

PMID 25173217

发布时间 2016-11-25

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Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice.

Experimental neurology

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Experimental neurology

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Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice.

Experimental neurology

相似文献

Experimental neurology

相关期刊

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