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A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis.

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第一作者： Jessica A,Hennessey

第一单位： Department of Medicine/Cardiology, Duke University School of Medicine, Durham, North Carolina, United States of America; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America.

作者： Jessica A,Hennessey ^[1] ; Nicole J,Boczek ^[2] ; Yong-Hui,Jiang ^[3] ; Joelle D,Miller ^[4] ; William,Patrick ^[5] ; Ryan,Pfeiffer ^[6] ; Brittan S,Sutphin ^[2] ; David J,Tester ^[2] ; Hector,Barajas-Martinez ^[6] ; Michael J,Ackerman ^[7] ; Charles,Antzelevitch ^[6] ; Ronald,Kanter ^[8] ; Geoffrey S,Pitt ^[9]

作者单位： Department of Medicine/Cardiology, Duke University School of Medicine, Durham, North Carolina, United States of America; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America. ^[1] Departments of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America. ^[2] Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, United States of America; Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, United States of America. ^[3] Department of Pediatrics, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, United States of America. ^[4] Department of Medicine/Cardiology, Duke University School of Medicine, Durham, North Carolina, United States of America. ^[5] Masonic Medical Research Laboratory, Utica, New York, United States of America. ^[6] Departments of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America; Departments of Internal Medicine and Pediatrics & Adolescent Medicine/Divisions of Cardiovascular Diseases and Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, United States of America. ^[7] Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, United States of America; Department of Pediatrics/Cardiology, Duke University School of Medicine, Durham, North Carolina, United States of America. ^[8] Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America; Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, United States of America. ^[9]