换一批
换一批PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.
第一作者：
F A,Schroeder
第一单位：
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School , Charlestown, Massachusetts 02129, United States.
作者：
主题词
动物(Animals);抗抑郁药(Antidepressive Agents);苯甲酰胺类(Benzamides);脑(Brain);碳放射性同位素(Carbon Radioisotopes);抑郁症(Depressive Disorder);疾病模型, 动物(Disease Models, Animal);后成说, 遗传(Epigenesis, Genetic);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);组蛋白脱乙酰基酶类(Histone Deacetylases);运动活动(Motor Activity);正电子发射断层显像术(Positron-Emission Tomography);放射性药物(Radiopharmaceuticals);大鼠(Rats)
DOI
10.1021/cn500162j
PMID
25188794
发布时间
2021-10-21
- 浏览19
ACS chemical neuroscience
1055-62页
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