Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.
第一作者:
Mirko,Andreoli
第一单位:
Danbury Hospital Research Institute , 24 Hospital Avenue, Danbury, Connecticut 06810, United States.
作者:
主题词
抗肿瘤药(Antineoplastic Agents);结合部位(Binding Sites);细胞系, 肿瘤(Cell Line, Tumor);计算生物学(Computational Biology);药物发现(Drug Discovery);抗药性, 肿瘤(Drug Resistance, Neoplasm);GTP结合蛋白质类(GTP-Binding Proteins);人类(Humans);模型, 分子(Models, Molecular);紫杉酚(Paclitaxel);原癌基因蛋白质c-pim-1(Proto-Oncogene Proteins c-pim-1)
DOI
10.1021/jm5009902
PMID
25211704
发布时间
2024-06-15
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