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Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.

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第一作者： Zhiyong,Liu

第一单位： From the Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology and Center for Biophysical Sciences and Engineering, Department of Optometry, The University of Alabama at Birmingham, Birmingham, Alabama 35294 and.

作者： Zhiyong,Liu ^[1] ; Robert A,Galemmo ^[2] ; Kyle B,Fraser ^[3] ; Mark S,Moehle ^[3] ; Saurabh,Sen ^[3] ; Laura A,Volpicelli-Daley ^[3] ; Lawrence J,DeLucas ^[2] ; Larry J,Ross ^[2] ; Jacob,Valiyaveettil ^[2] ; Omar,Moukha-Chafiq ^[2] ; Ashish K,Pathak ^[2] ; Subramaniam,Ananthan ^[2] ; Hollis,Kezar ^[2] ; E Lucile,White ^[2] ; Vandana,Gupta ^[2] ; Joseph A,Maddry ^[2] ; Mark J,Suto ^[2] ; Andrew B,West ^[4]

作者单位： From the Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology and Center for Biophysical Sciences and Engineering, Department of Optometry, The University of Alabama at Birmingham, Birmingham, Alabama 35294 and. ^[1] the Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35294. ^[2] From the Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology and. ^[3] From the Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology and abwest@uab.edu. ^[4]

关键词 Alphascreen High-throughput Screening (HTS)Kinase Inhibitor Leucine-rich Repeat Kinase 2 (LRRK2)Neurodegeneration Park8 Protein Kinase Recombinant Protein Expression