换一批
换一批Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.
第一作者：
Thomas S,Dexheimer
第一单位：
National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
作者：
主题词
抗肿瘤药(Antineoplastic Agents);拟南芥蛋白质类(Arabidopsis Proteins);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);肺肿瘤(Lung Neoplasms);核蛋白质类(Nuclear Proteins);增殖细胞核抗原(Proliferating Cell Nuclear Antigen);嘧啶类(Pyrimidines);构效关系(Structure-Activity Relationship);泛素化(Ubiquitination)
DOI
10.1021/jm5010495
PMID
25229643
发布时间
2021-10-21
- 浏览24
Journal of medicinal chemistry
8099-110页
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