IFNγ⁻TNFα⁻IL2⁻MIP1α⁻CD107a⁺PRF1⁺ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans.

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作者： Sara,Ferrando-Martínez ^[1] ; Ezequiel,Ruiz-Mateos ^[2] ; Joseph P,Casazza ^[3] ; Rebeca S,de Pablo-Bernal ^[2] ; Beatriz,Dominguez-Molina ^[2] ; M Ángeles,Muñoz-Fernández ^[4] ; Juan,Delgado ^[5] ; Rafael,de la Rosa ^[5] ; Rafael,Solana ^[6] ; Richard A,Koup ^[3] ; Manuel,Leal ^[2]

作者单位： Laboratorio de InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain. Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital, Sevilla, Spain. ^[1] Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital, Sevilla, Spain. ^[2] Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland. ^[3] Laboratorio de InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain. ^[4] Internal Medicine Service, Hospital San Juan de Dios del Aljarafe, Bormujos, Spain. ^[5] Department of Cellular Immunology, IMIBIC-Reina Sofía University Hospital, University of Córdoba, Spain. ^[6]

关键词 Aging CMV CMV-specific T-cell response Mortality Perforin