PCSK9 polymorphism in a Tunisian cohort: identification of a new allele, L8, and association of allele L10 with reduced coronary heart disease risk.

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作者： Afef,Slimani ^[1] ; Mohamed Yahia,Hrira ^[2] ; Mohamed,Najah ^[3] ; Walid,Jomaa ^[4] ; Faouzi,Maatouk ^[4] ; Khaldoun Ben,Hamda ^[4] ; Marianne,Abifadel ^[5] ; Jean-Pierre,Rabès ^[6] ; Catherine,Boileau ^[7] ; Mustapha,Rouis ^[8] ; Mohamed Naceur,Slimane ^[3] ; Mathilde,Varret ^[9]

作者单位： Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine, Monastir 5000, Tunisia. Electronic address: afefslimani@yahoo.com. ^[1] Laboratory of Molecular Biology, University of Pharmacy, Monastir 5000, Tunisia. ^[2] Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine, Monastir 5000, Tunisia. ^[3] Department of Cardiovascular Diseases, Fattouma Bourguiba Hospital, Monastir 5000, Tunisia. ^[4] Faculté de Pharmacie, Université Saint Joseph, Bierut, Lebanon; LVTS, INSERM U1148, Laboratory for Vascular Translational Science & Université Denis Diderot, Paris, France. ^[5] LVTS, INSERM U1148, Laboratory for Vascular Translational Science & Université Denis Diderot, Paris, France; AP-HP, Hôpital A. Paré, Boulogne-Billancourt & UFR des Sciences de la Santé, Université Versailles Saint Quentin-en-Yvelines, France. ^[6] LVTS, INSERM U1148, Laboratory for Vascular Translational Science & Université Denis Diderot, Paris, France; AP-HP, CHU Xavier Bichat, Département de Génétique, Paris, France. ^[7] UR 4-Vieillissement, Stress, Inflammation, Un iversité Pierre et Marie Curie, Paris, France. ^[8] LVTS, INSERM U1148, Laboratory for Vascular Translational Science & Université Denis Diderot, Paris, France. ^[9]

关键词 Coronary artery disease PCSK9 gene c.61_63dupCTG rs72555377