Silencing of PNPLA6, the neuropathy target esterase (NTE) codifying gene, alters neurodifferentiation of human embryonal carcinoma stem cells (NT2).

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第一作者： D,Pamies

第一单位： Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, 03202, Spain; Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, VA 21027, Italy. Electronic address: dpamies@jhsph.edu.

作者： D,Pamies ^[1] ; A,Bal-Price ^[2] ; M,Fabbri ^[3] ; L,Gribaldo ^[2] ; B,Scelfo ^[2] ; G,Harris ^[4] ; A,Collotta ^[2] ; E,Vilanova ^[5] ; M A,Sogorb ^[5]

作者单位： Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, 03202, Spain; Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, VA 21027, Italy. Electronic address: dpamies@jhsph.edu. ^[1] Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, VA 21027, Italy. ^[2] Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, VA 21027, Italy; Università degli Studi dell'Insubria, Department of Clinical and Experimental Medicine, Via Dunant, 5, Varese 21100, Italy. ^[3] Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, VA 21027, Italy. ^[4] Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, 03202, Spain. ^[5]

关键词 PNPLA6 hNT2 in vitro neurodifferentiation neuropathy target esterase silencing

主题词羧酸酯水解酶类(Carboxylic Ester Hydrolases);细胞分化(Cell Differentiation);胚胎性癌干细胞(Embryonal Carcinoma Stem Cells);基因表达(Gene Expression);基因沉默(Gene Silencing);人类(Humans);磷脂酶类(Phospholipases)

DOI 10.1016/j.neuroscience.2014.08.031

PMID 25255935

发布时间 2018-01-26

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