The yeast model suggests the use of short peptides derived from mt LeuRS for the therapy of diseases due to mutations in several mt tRNAs.

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第一作者： Patrizio,Di Micco

第一单位： Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.

作者： Patrizio,Di Micco ^[1] ; Mario,Fazzi D'Orsi ^[2] ; Veronica,Morea ^[3] ; Laura,Frontali ^[4] ; Silvia,Francisci ^[4] ; Arianna,Montanari ^[5]

作者单位： Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy. ^[1] Department of Biology and Biotechnologies "C. Darwin", Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy. ^[2] National Research Council of Italy (CNR) - Institute of Biology, Molecular Medicine and Nanobiotechnology (IBMN), Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy. ^[3] Department of Biology and Biotechnologies "C. Darwin", Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy; Pasteur Institute - Cenci Bolognetti Foundation, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy. ^[4] Department of Biology and Biotechnologies "C. Darwin", Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy. Electronic address: ari.montanari@uniroma1.it. ^[5]

关键词 Aminoacyl tRNA synthetases C-term domain Mitochondrial diseases Mitochondrial tRNA mutations Suppressive sequences

DOI 10.1016/j.bbamcr.2014.09.011

PMID 25261707

发布时间 2022-01-29

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