Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1.

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作者： Tae Yun,Kim ^[1] ; Yukiko,Kunitomo ^[1] ; Zachary,Pfeiffer ^[1] ; Divyang,Patel ^[2] ; Jungmin,Hwang ^[3] ; Kathryn,Harrison ^[1] ; Brijesh,Patel ^[1] ; Paul,Jeng ^[1] ; Ohad,Ziv ^[4] ; Yichun,Lu ^[1] ; Xuwen,Peng ^[5] ; Zhilin,Qu ^[6] ; Gideon,Koren ^[1] ; Bum-Rak,Choi ^[7]

作者单位： Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island. ^[1] Cardiovascular Institutes, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. ^[2] Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Pharmacology, University of Rhode Island, Kingston, Rhode Island. ^[3] Case Western Reserve University, School of Medicine, Cleveland, Ohio. ^[4] Department of Comparative Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. ^[5] Department of Medicine, University of California, Los Angeles, California. ^[6] Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: Bum-Rak_Choi@brown.edu. ^[7]

关键词 Action potential duration dispersion Bi-excitability Early afterdepolarization Long QT syndrome Optical mapping Polymorphic ventricular tachycardia Ventricular tachycardia