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Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

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作者: Coffee and Caffeine Genetics Consortium [1] ; Marilyn C,Cornelis [2] ; Enda M,Byrne [3] ; Tõnu,Esko [4] ; Michael A,Nalls [5] ; Andrea,Ganna [6] ; Nina,Paynter [7] ; Keri L,Monda [8] ; Najaf,Amin [9] ; Krista,Fischer [10] ; Frida,Renstrom [11] ; Julius S,Ngwa [12] ; Ville,Huikari [4] ; Alana,Cavadino [13] ; Ilja M,Nolte [14] ; Alexander,Teumer [15] ; Kai,Yu [16] ; Pedro,Marques-Vidal [17] ; Rajesh,Rawal [18] ; Ani,Manichaikul [19] ; Mary K,Wojczynski [20] ; Jacqueline M,Vink [21] ; Jing Hua,Zhao [22] ; George,Burlutsky [23] ; Jari,Lahti [24] ; Vera,Mikkilä [25] ; Rozenn N,Lemaitre [26] ; Joel,Eriksson [27] ; Solomon K,Musani [28] ; Toshiko,Tanaka [29] ; Frank,Geller [30] ; Jian'an,Luan [31] ; Jennie,Hui [32] ; Reedik,Mägi [33] ; Maria,Dimitriou [34] ; Melissa E,Garcia [35] ; Weang-Kee,Ho [25] ; Margaret J,Wright [36] ; Lynda M,Rose [37] ; Patrik Ke,Magnusson [38] ; Nancy L,Pedersen [39] ; David,Couper [4] ; Ben A,Oostra [40] ; Albert,Hofman [41] ; Mohammad Arfan,Ikram [42] ; Henning W,Tiemeier [43] ; Andre G,Uitterlinden [10] ; Frank Ja,van Rooij [9] ; Inês,Barroso [9] ; Ingegerd,Johansson [44] ; Luting,Xue [45] ; Marika,Kaakinen [12] ; Lili,Milani [12] ; Chris,Power [46] ; Harold,Snieder [47] ; Ronald P,Stolk [12] ; Sebastian E,Baumeister [48] ; Reiner,Biffar [12] ; Fangyi,Gu [49] ; François,Bastardot [12] ; Zoltán,Kutalik [50] ; David R,Jacobs [51] ; Nita G,Forouhi [52] ; Evelin,Mihailov [14] ; Lars,Lind [15] ; Cecilia,Lindgren [53] ; Karl,Michaëlsson [54] ; Andrew,Morris [4] ; Majken,Jensen [16] ; Kay-Tee,Khaw [17] ; Robert N,Luben [17] ; Jie Jin,Wang [55] ; Satu,Männistö [56] ; Mia-Maria,Perälä [19] ; Mika,Kähönen [57] ; Terho,Lehtimäki [58] ; Jorma,Viikari [59] ; Dariush,Mozaffarian [60] ; Kenneth,Mukamal [61] ; Bruce M,Psaty [25] ; Angela,Döring [4] ; Andrew C,Heath [62] ; Grant W,Montgomery [63] ; Norbert,Dahmen [64] ; Teresa,Carithers [63] ; Katherine L,Tucker [2] ; Luigi,Ferrucci [42] ; Heather A,Boyd [42] ; Mads,Melbye [26] ; Jorien L,Treur [65] ; Dan,Mellström [65] ; Jouke Jan,Hottenga [66] ; Inga,Prokopenko [67] ; Anke,Tönjes [68] ; Panos,Deloukas [1] ; Stavroula,Kanoni [2] ; Mattias,Lorentzon [69] ; Denise K,Houston [70] ; Yongmei,Liu [31] ; John,Danesh [71] ; Asif,Rasheed [72] ; Marc A,Mason [73] ; Alan B,Zonderman [74] ; Lude,Franke [75] ; Bruce S,Kristal [43] ; International Parkinson’s Disease Genomics Consortium (IPDGC) [76] ; North American Brain Expression Consortium (NABEC) [77] ; UK Brain Expression Consortium (UKBEC) [78] ; Juha,Karjalainen [34] ; Danielle R,Reed [35] ; Harm-Jan,Westra [35] ; Michele K,Evans [24] ; Danish,Saleheen [32] ; Tamara B,Harris [24] ; George,Dedoussis [63] ; Gary,Curhan [79] ; Michael,Stumvoll [80] ; John,Beilby [81] ; Louis R,Pasquale [50] ; Bjarke,Feenstra [82] ; Stefania,Bandinelli [83] ; Jose M,Ordovas [82] ; Andrew T,Chan [32] ; Ulrike,Peters [84] ; Claes,Ohlsson [84] ; Christian,Gieger [42] ; Nicholas G,Martin [85] ; Melanie,Waldenberger [86] ; David S,Siscovick [87] ; Olli,Raitakari [88] ; Johan G,Eriksson [89] ; Paul,Mitchell [90] ; David J,Hunter [88] ; Peter,Kraft [91] ; Eric B,Rimm [88] ; Dorret I,Boomsma [86] ; Ingrid B,Borecki [42] ; Ruth Jf,Loos [85] ; Nicholas J,Wareham [41] ; Peter,Vollenweider [40] ; Neil,Caporaso [1] ; Hans Jörgen,Grabe [80] ; Marian L,Neuhouser [81] ; Bruce Hr,Wolffenbuttel [36] ; Frank B,Hu [37] ; Elina,Hyppönen [38] ; Marjo-Riitta,Järvelin [1] ; L Adrienne,Cupples [92] ; Paul W,Franks [35] ; Paul M,Ridker [93] ; Cornelia M,van Duijn [94] ; Gerardo,Heiss [1] ; Andres,Metspalu [95] ; Kari E,North [96] ; Erik,Ingelsson [32] ; Jennifer A,Nettleton [21] ; Rob M,van Dam [43] ; Daniel I,Chasman [97]
作者单位: Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [1] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. [2] The University of Queensland, Queensland Brain Institute, Queensland, Australia. [3] Estonian Genome Center, University of Tartu, Tartu, Estonia. [4] Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA. [5] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [6] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [7] Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health (NIH), Bethesda, Maryland, USA. [8] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska, Sweden. [9] Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [10] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [11] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [12] Department of Clinical Sciences, Lund University, Malmö, Sweden. [13] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. [14] Institute of Health Sciences, University of Oulu, Oulu, Finland. [15] Centre for Paediatric Epidemiology and Biostatistics, Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK. [16] Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands. [17] Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany. [18] Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. [19] Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. [20] Institute of Genetic Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany. [21] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [22] Washington University School of Medicine, Department of Genetics, Division of Statistical Genomics, St Louis, Missouri, USA. [23] Department of Biological Psychology / Netherlands Twin Register, VU University, Amsterdam, The Netherlands. [24] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK. [25] Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, New South Wales, Australia. [26] Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland. [27] Folkhälsan Research Centre, Helsinki, Finland. [28] Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland. [29] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland. [30] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA. [31] Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. [32] University of Mississippi Medical Center, Jackson, Mississippi, USA. [33] Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA. [34] Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark. [35] Busselton Population Medical Research Foundation Inc., Busselton, Australia. [36] PathWest Laboratory Medicine WA, Nedlands, Western Australia. [37] School of Pathology & Laboratory Medicine, The University of Western Australia, Nedlands, Western Australia. [38] School of Population Health, The University of Western Australia, Nedlands, Western Australia. [39] Harokopio University, Athens, Greece. [40] Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA. [41] Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK. [42] QIMR Berghofer Medical Research Institute, Queensland, Australia. [43] Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [44] Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands. [45] Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands. [46] Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. [47] Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands. [48] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. [49] Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. [50] University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Cambridge, UK. [51] Department of Odontology, Umeå University, Umeå, Sweden. [52] Biocenter Oulu, University of Oulu, Oulu, Finland. [53] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK. [54] Institute for Community Medicine, University Medicine Greifswald, Germany. [55] Department of Prosthodontics, Gerodontology and Biomaterials, Center of Oral Health, University Medicine Greifswald, Germany. [56] Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. [57] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. [58] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. [59] Swiss Institute of Bioinformatics, Lausanne, Switzerland. [60] Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA. [61] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [62] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [63] Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. [64] Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. [65] Department of Clinical Physiology, Tampere University Hospital and School of Medicine University of Tampere, Tampere, Finland. [66] Department of Clinical Chemistry, Fimlab Laboratories, and School of Medicine, University of Tampere, Tampere, Finland. [67] Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland. [68] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [69] Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. [70] Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, Washington, USA. [71] Department of Health Services, University of Washington, Seattle, Washington, USA. [72] Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA. [73] Institute of Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany. [74] Department of Psychiatry, Washington University, St.Louis, Missouri, USA. [75] Department for Psychiatry, Johannes-Gutenberg-University, Mainz, Germany. [76] School of Applied Sciences, University of Mississippi, Oxford, Mississippi, USA. [77] Clinical Laboratory & Nutritional Sciences, University of Massachusetts Lowell, Lowell, Massachusetts, USA. [78] Department of Genomics of Common Diseases, Imperial College London, London, UK. [79] Medical Department, University of Leipzig, Germany. [80] IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany. [81] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [82] King Abdulaziz University, Jeddah, Saudi Arabia. [83] Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. [84] Center for Non-Communicable Diseases, Pakistan. [85] Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA. [86] Laboratory of Personality and Cognition, National Institute on Aging, NIH, Baltimore, Maryland, USA. [87] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. [88] Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA. [89] Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA. [90] Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA. [91] Mass Eye and Ear Infirmary, Boston, Massachusetts, USA. [92] Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy. [93] Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. [94] Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA. [95] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [96] Research Unit of Molecular Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany. [97] Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. [98] Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland. [99] Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland. [100] Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA. [101] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. [102] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. [103] Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hospital Stralsund, Germany. [104] Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [105] Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. [106] School of Population Health, University of South Australia, Adelaide, Australia. [107] South Australian Health and Medical Research Institute, Adelaide, Australia. [108] Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland. [109] Unit of Primary Care, Oulu University Hospital, Oulu, Finland. [110] The Framingham Heart Study, Framingham, Massachusetts, USA. [111] Department of Public Health & Clinical Medicine, Section for Medicine, Umeå University, Umeå, Sweden. [112] Netherlands Consortium for Healthy Ageing and National Genomics Initiative, Leiden, The Netherlands. [113] Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA. [114] Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. [115]
DOI 10.1038/mp.2014.107
PMID 25288136
发布时间 2023-02-09
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