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首页> Molecular therapy : the journal of the American Society of Gene Therapy> First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity.

First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity.

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作者： Herbert J,Zeh ^[1] ; Stephanie,Downs-Canner ^[1] ; J Andrea,McCart ^[2] ; Zong Sheng,Guo ^[1] ; Uma N M,Rao ^[3] ; Lekshmi,Ramalingam ^[1] ; Stephen H,Thorne ^[1] ; Heather L,Jones ^[1] ; Pawel,Kalinski ^[1] ; Eva,Wieckowski ^[1] ; Mark E,O'Malley ^[1] ; Manijeh,Daneshmand ^[4] ; Kang,Hu ^[4] ; John C,Bell ^[4] ; Tae-Ho,Hwang ^[5] ; Anne,Moon ^[6] ; Caroline J,Breitbach ^[6] ; David H,Kirn ^[6] ; David L,Bartlett ^[1]

作者单位： Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. ^[1] Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada. ^[2] Department of Pathology, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. ^[3] Center for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. ^[4] 1] Department of Pharmacology, Pusan National University, Busan, South Korea [2] SillaJen, Inc., Seoul, South Korea. ^[5] SillaJen, Inc., Seoul, South Korea. ^[6]

主题词老年人(Aged);动物(Animals);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);结肠肿瘤(Colonic Neoplasms);剂量效应关系, 免疫(Dose-Response Relationship, Immunologic);女(雌)性(Female);基因缺失(Gene Deletion);人类(Humans);注射, 病灶内(Injections, Intralesional);男(雄)性(Male);黑色素瘤(Melanoma);中年人(Middle Aged);溶瘤病毒疗法(Oncolytic Virotherapy);溶瘤病毒(Oncolytic Viruses);胰腺肿瘤(Pancreatic Neoplasms);皮肤肿瘤(Skin Neoplasms);痘苗病毒(Vaccinia virus);病毒复制(Virus Replication)

DOI 10.1038/mt.2014.194

PMID 25292189

发布时间 2022-03-31

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Molecular therapy : the journal of the American Society of Gene Therapy

Molecular therapy

2015年23卷1期

202-14页

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