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Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes.

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第一作者: Monika Julia,Wolf
第一单位: Institute of Surgical Pathology, University Hospital Zurich, Zurich 8091, Switzerland.
作者单位: Institute of Surgical Pathology, University Hospital Zurich, Zurich 8091, Switzerland. [1] Institute of Virology, Technische Universität München and Helmholtz Zentrum München, Munich 81675, Germany. [2] LIMES Life and Medical Sciences Institute, University of Bonn, Bonn 53125, Germany. [3] Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, Bonn 53105, Germany. [4] Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München & Division of Metabolic Diseases, Technische Universität München, Munich 81657, Germany. [5] Institute of Virology, Technische Universität München and Helmholtz Zentrum München, Munich 81675, Germany; Second Medical Department, Klinikum Rechts der Isar, Technische Universität München, Munich 81657, Germany. [6] Institute of Molecular Immunology, Technische Universität München, Munich 81675, Germany. [7] Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg 85764, Germany. [8] Junior Group Intestinal Microbiome, Technische Universität München, Freising-Weihenstephan 85350, Germany; Chair of Nutrition and Immunology, ZIEL-Research Center for Nutrition and Food Sciences, Biofunctionality Unit, Technische Universität München, Freising-Weihenstephan 85350, Germany. [9] Trudeau Institute, Saranac Lake, New York, NY 12983, USA. [10] Chair of Nutrition and Immunology, ZIEL-Research Center for Nutrition and Food Sciences, Biofunctionality Unit, Technische Universität München, Freising-Weihenstephan 85350, Germany. [11] Research Unit of Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany. [12] Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego, School of Medicine, San Diego, CA 92093, USA. [13] Molecular Biomedicine, Institute of Molecular Health Sciences, ETH Zurich, Zurich 8093, Switzerland. [14] Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, Bonn 53105, Germany; Institute of Molecular Immunology, Technische Universität München, Munich 81675, Germany. [15] Institute of Surgical Pathology, University Hospital Zurich, Zurich 8091, Switzerland. Electronic address: achim.weber@usz.ch. [16] Institute of Virology, Technische Universität München and Helmholtz Zentrum München, Munich 81675, Germany. Electronic address: heikenwaelder@helmholtz-muenchen.de. [17]
DOI 10.1016/j.ccell.2014.09.003
PMID 25314080
发布时间 2022-04-08
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