Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes.

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作者： Ashley J,Pratt ^[1] ; David S,Shin ^[1] ; Gregory E,Merz ^[2] ; Robert P,Rambo ^[3] ; W Andrew,Lancaster ^[4] ; Kevin N,Dyer ^[3] ; Peter P,Borbat ^[5] ; Farris L,Poole ^[4] ; Michael W W,Adams ^[4] ; Jack H,Freed ^[5] ; Brian R,Crane ^[2] ; John A,Tainer ^[6] ; Elizabeth D,Getzoff ^[7]

作者单位： Department of Integrative Structural and Computational Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037; Life Sciences and. ^[1] Department of Chemistry and Chemical Biology and. ^[2] Physical Biosciences Divisions, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; ^[3] Department of Biochemistry, University of Georgia, Athens, GA 30602. ^[4] Center for Advanced ESR Studies (ACERT), Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853-1301; and. ^[5] Department of Integrative Structural and Computational Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037; Life Sciences and jat@scripps.edu edg@scripps.edu. ^[6] Department of Integrative Structural and Computational Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037; jat@scripps.edu edg@scripps.edu. ^[7]

关键词 ESR spectroscopy Lou Gehrig’s disease protein aggregation protein conformation small-angle X-ray scattering