The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.-论文-万方医学网

作者： Joni,Van der Meulen ^[1] ; Viraj,Sanghvi ^[2] ; Konstantinos,Mavrakis ^[2] ; Kaat,Durinck ^[1] ; Fang,Fang ^[3] ; Filip,Matthijssens ^[1] ; Pieter,Rondou ^[1] ; Monica,Rosen ^[3] ; Tim,Pieters ^[4] ; Peter,Vandenberghe ^[5] ; Eric,Delabesse ^[6] ; Tim,Lammens ^[7] ; Barbara,De Moerloose ^[7] ; Björn,Menten ^[1] ; Nadine,Van Roy ^[1] ; Bruno,Verhasselt ^[8] ; Bruce,Poppe ^[1] ; Yves,Benoit ^[7] ; Tom,Taghon ^[8] ; Ari M,Melnick ^[3] ; Frank,Speleman ^[1] ; Hans-Guido,Wendel ^[2] ; Pieter,Van Vlierberghe ^[1]

作者单位： Center for Medical Genetics, Ghent University, Ghent, Belgium; ^[1] Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY; ^[2] Department of Medicine, Weill Cornell Medical College, New York, NY; ^[3] Center for Medical Genetics, Ghent University, Ghent, Belgium; Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium; ^[4] Centre for Human Genetics, University Hospital Leuven, Leuven, Belgium; ^[5] INSERM U563, Toulouse, France; ^[6] Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium; and. ^[7] Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium. ^[8]

主题词等位基因(Alleles);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);队列研究(Cohort Studies);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);基因表达调控, 白血病(Gene Expression Regulation, Leukemic);组蛋白脱甲基酶类(Histone Demethylases);组蛋白类(Histones);人类(Humans);免疫表型分型(Immunophenotyping);白细胞介素类(Interleukins);男(雄)性(Male);小鼠(Mice);突变(Mutation);核蛋白质类(Nuclear Proteins);多态性, 单核苷酸(Polymorphism, Single Nucleotide);前体T细胞淋巴母细胞白血病淋巴瘤(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma);性别因素(Sex Factors);T淋巴细胞(T-Lymphocytes)

DOI 10.1182/blood-2014-05-577270

PMID 25320243

发布时间 2021-10-21

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The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.

Blood

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The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.

Blood

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Blood

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