Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease.

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作者： Claudio,Liguori ^[1] ; Andrea,Romigi ^[1] ; Marzia,Nuccetelli ^[2] ; Silvana,Zannino ^[1] ; Giuseppe,Sancesario ^[3] ; Alessandro,Martorana ^[3] ; Maria,Albanese ^[1] ; Nicola Biagio,Mercuri ^[4] ; Francesca,Izzi ^[1] ; Sergio,Bernardini ^[2] ; Alessandra,Nitti ^[1] ; Giulia M,Sancesario ^[5] ; Francesco,Sica ^[6] ; Maria G,Marciani ^[6] ; Fabio,Placidi ^[1]

作者单位： Neurophysiopathology Unit, Sleep Medicine Centre, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. ^[1] Department of Clinical Biochemistry and Molecular Biology, University of Rome Tor Vergata, Rome, Italy. ^[2] Neurology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy4Neuroscience Unit, Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy. ^[3] Neurophysiopathology Unit, Sleep Medicine Centre, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy4Neuroscience Unit, Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy. ^[4] Neuroscience Unit, Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy. ^[5] Neurology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. ^[6]

主题词老年人(Aged);老年人, 80以上(Aged, 80 and over);阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);病例对照研究(Case-Control Studies);认知障碍(Cognition Disorders);女(雌)性(Female);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);男(雄)性(Male);中年人(Middle Aged);神经肽类(Neuropeptides);肽碎片(Peptide Fragments);多道睡眠描记术(Polysomnography);疾病严重程度指数(Severity of Illness Index);tau蛋白质类(tau Proteins)

DOI 10.1001/jamaneurol.2014.2510

PMID 25322206

发布时间 2015-11-19

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JAMA neurology

2014年71卷12期

1498-505页

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Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease.

JAMA neurology

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JAMA neurology

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Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease.

JAMA neurology

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JAMA neurology

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