A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.-论文-万方医学网

第一作者： Nina,Schönhuber

第一单位： Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany.

作者： Nina,Schönhuber ^[1] ; Barbara,Seidler ^[1] ; Kathleen,Schuck ^[1] ; Christian,Veltkamp ^[1] ; Christina,Schachtler ^[1] ; Magdalena,Zukowska ^[1] ; Stefan,Eser ^[1] ; Thorsten B,Feyerabend ^[2] ; Mariel C,Paul ^[1] ; Philipp,Eser ^[3] ; Sabine,Klein ^[1] ; Andrew M,Lowy ^[4] ; Ruby,Banerjee ^[5] ; Fangtang,Yang ^[5] ; Chang-Lung,Lee ^[6] ; Everett J,Moding ^[7] ; David G,Kirsch ^[8] ; Angelika,Scheideler ^[9] ; Dario R,Alessi ^[10] ; Ignacio,Varela ^[11] ; Allan,Bradley ^[5] ; Alexander,Kind ^[12] ; Angelika E,Schnieke ^[12] ; Hans-Reimer,Rodewald ^[2] ; Roland,Rad ^[13] ; Roland M,Schmid ^[14] ; Günter,Schneider ^[1] ; Dieter,Saur ^[14]

作者单位： Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany. ^[1] German Cancer Research Center (DKFZ), Division for Cellular Immunology, Heidelberg, Germany. ^[2] Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universität München, München, Germany. ^[3] Moores Cancer Center, Division of Surgical Oncology, University of California San Diego, La Jolla, California, USA. ^[4] Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, UK. ^[5] Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA. ^[6] Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA. ^[7] Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA.;Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA. ^[8] Helmholtz Zentrum München, Research Unit Comparative Medicine, Neuherberg, Germany. ^[9] MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK. ^[10] Instituto de Biomedicina y Biotecnología de Cantabria (CSIC-UC-Sodercan), Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain. ^[11] Livestock Biotechnology, Technische Universität München, Freising, Germany. ^[12] Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany.;Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, UK.;German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. ^[13] Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany.;German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. ^[14]

医学主题词腺癌(Adenocarcinoma);动物(Animals);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞谱系(Cell Lineage);女(雌)性(Female);遗传工程(Genetic Engineering);绿色荧光蛋白质类(Green Fluorescent Proteins);男(雄)性(Male);肥大细胞(Mast Cells);小鼠(Mice);模型, 生物学(Models, Biological);分子靶向治疗(Molecular Targeted Therapy);肿瘤转移(Neoplasm Metastasis);癌基因(Oncogenes);胰腺(Pancreas);癌前状态(Precancerous Conditions);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));重组酶类(Recombinases);结果可重复性(Reproducibility of Results);种特异性(Species Specificity);间质细胞(Stromal Cells);他莫昔芬(Tamoxifen);时间因素(Time Factors)

DOI 10.1038/nm.3646

PMID 25326799

发布时间 2025-05-29

基金项目

R01 CA155620/CA/NCI NIH HHS/United States K02 AI093866/AI/NIAID NIH HHS/United States R01 CA138265/CA/NCI NIH HHS/United States MC_EX_G0802532/MRC_/Medical Research Council/United Kingdom MC_UU_12016/2/MRC_/Medical Research Council/United Kingdom P30 CA023100/CA/NCI NIH HHS/United States CA155620/CA/NCI NIH HHS/United States 233074/ERC_/European Research Council/International

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A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

Nature medicine

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A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

Nature medicine

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Nature medicine

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