换一批Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
第一作者：
Paolo,Peterlongo
第一单位：
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy. paolo.peterlongo@ifom.eu eitan.friedman@sheba.health.gov.il feitan@post.tau.ac.il.
作者：
Paolo,Peterlongo [1]
;
Jenny,Chang-Claude [2]
;
Kirsten B,Moysich [3]
;
Anja,Rudolph [2]
;
Rita K,Schmutzler [4]
;
Jacques,Simard [5]
;
Penny,Soucy [5]
;
Rosalind A,Eeles [6]
;
Douglas F,Easton [7]
;
Ute,Hamann [8]
;
Stefan,Wilkening [9]
;
Bowang,Chen [10]
;
Matti A,Rookus [11]
;
Marjanka K,Schmidt [12]
;
Frederieke H,van der Baan [11]
;
Amanda B,Spurdle [13]
;
Logan C,Walker [14]
;
Felicity,Lose [13]
;
Ana-Teresa,Maia [15]
;
Marco,Montagna [16]
;
Laura,Matricardi [16]
;
Jan,Lubinski [17]
;
Anna,Jakubowska [17]
;
Encarna B,Gómez Garcia [18]
;
Olufunmilayo I,Olopade [19]
;
Robert L,Nussbaum [20]
;
Katherine L,Nathanson [21]
;
Susan M,Domchek [21]
;
Timothy R,Rebbeck [22]
;
Banu K,Arun [23]
;
Beth Y,Karlan [24]
;
Sandra,Orsulic [24]
;
Jenny,Lester [24]
;
Wendy K,Chung [25]
;
Alex,Miron [26]
;
Melissa C,Southey [27]
;
David E,Goldgar [28]
;
Saundra S,Buys [29]
;
Ramunas,Janavicius [30]
;
Cecilia M,Dorfling [31]
;
Elizabeth J,van Rensburg [31]
;
Yuan Chun,Ding [32]
;
Susan L,Neuhausen [32]
;
Thomas V O,Hansen [33]
;
Anne-Marie,Gerdes [34]
;
Bent,Ejlertsen [35]
;
Lars,Jønson [33]
;
Ana,Osorio [36]
;
Cristina,Martínez-Bouzas [37]
;
Javier,Benitez [38]
;
Edye E,Conway [39]
;
Kathleen R,Blazer [40]
;
Jeffrey N,Weitzel [41]
;
Siranoush,Manoukian [42]
;
Bernard,Peissel [42]
;
Daniela,Zaffaroni [42]
;
Giulietta,Scuvera [42]
;
Monica,Barile [43]
;
Filomena,Ficarazzi [44]
;
Frederique,Mariette [44]
;
Stefano,Fortuzzi [44]
;
Alessandra,Viel [45]
;
Giuseppe,Giannini [46]
;
Laura,Papi [47]
;
Aline,Martayan [48]
;
Maria Grazia,Tibiletti [49]
;
Paolo,Radice [50]
;
Athanassios,Vratimos [51]
;
Florentia,Fostira [51]
;
Judy E,Garber [52]
;
Alan,Donaldson [53]
;
Carole,Brewer [54]
;
Claire,Foo [55]
;
D Gareth R,Evans [56]
;
Debra,Frost [7]
;
Diana,Eccles [57]
;
Angela,Brady [58]
;
Jackie,Cook [59]
;
Marc,Tischkowitz [60]
;
Julian,Adlard [61]
;
Julian,Barwell [62]
;
Lisa,Walker [63]
;
Louise,Izatt [64]
;
Lucy E,Side [65]
;
M John,Kennedy [66]
;
Mark T,Rogers [67]
;
Mary E,Porteous [68]
;
Patrick J,Morrison [69]
;
Radka,Platte [7]
;
Rosemarie,Davidson [70]
;
Shirley V,Hodgson [71]
;
Steve,Ellis [7]
;
Trevor,Cole [72]
;
EMBRACE [73]
;
Andrew K,Godwin [74]
;
Kathleen,Claes [74]
;
Tom,Van Maerken [75]
;
Alfons,Meindl [76]
;
Andrea,Gehrig [77]
;
Christian,Sutter [78]
;
Christoph,Engel [79]
;
Dieter,Niederacher [80]
;
Doris,Steinemann [81]
;
Hansjoerg,Plendl [82]
;
Karin,Kast [83]
;
Kerstin,Rhiem [84]
;
Nina,Ditsch [85]
;
Norbert,Arnold [86]
;
Raymonda,Varon-Mateeva [83]
;
Barbara,Wappenschmidt [87]
;
Shan,Wang-Gohrke [88]
;
Brigitte,Bressac-de Paillerets [89]
;
Bruno,Buecher [90]
;
Capucine,Delnatte [91]
;
Claude,Houdayer [92]
;
Dominique,Stoppa-Lyonnet [93]
;
Francesca,Damiola [94]
;
Isabelle,Coupier [95]
;
Laure,Barjhoux [96]
;
Laurence,Venat-Bouvet [89]
;
Lisa,Golmard [97]
;
Nadia,Boutry-Kryza [98]
;
Olga M,Sinilnikova [99]
;
Olivier,Caron [100]
;
Pascal,Pujol [93]
;
Sylvie,Mazoyer [89]
;
Muriel,Belotti [101]
;
GEMO Study Collaborators [102]
;
Marion,Piedmonte [103]
;
Michael L,Friedlander [104]
;
Gustavo C,Rodriguez [105]
;
Larry J,Copeland [106]
;
Miguel,de la Hoya [107]
;
Pedro Perez,Segura [108]
;
Heli,Nevanlinna [109]
;
Kristiina,Aittomäki [110]
;
Theo A M,van Os [111]
;
Hanne E J,Meijers-Heijboer [112]
;
Annemarie H,van der Hout [113]
;
Maaike P G,Vreeswijk [114]
;
Nicoline,Hoogerbrugge [115]
;
Margreet G E M,Ausems [116]
;
Helena C,van Doorn [117]
;
J Margriet,Collée [118]
;
HEBON [119]
;
Edith,Olah [120]
;
Orland,Diez [121]
;
Ignacio,Blanco [122]
;
Conxi,Lazaro [17]
;
Joan,Brunet [17]
;
Lidia,Feliubadalo [17]
;
Cezary,Cybulski [17]
;
Jacek,Gronwald [17]
;
Katarzyna,Durda [123]
;
Katarzyna,Jaworska-Bieniek [124]
;
Grzegorz,Sukiennicki [125]
;
Adalgeir,Arason [126]
;
Jocelyne,Chiquette [127]
;
Manuel R,Teixeira [128]
;
Curtis,Olswold [129]
;
Fergus J,Couch [130]
;
Noralane M,Lindor [131]
;
Xianshu,Wang [132]
;
Csilla I,Szabo [132]
;
Kenneth,Offit [131]
;
Marina,Corines [133]
;
Lauren,Jacobs [131]
;
Mark E,Robson [134]
;
Liying,Zhang [134]
;
Vijai,Joseph [134]
;
Andreas,Berger [134]
;
Christian F,Singer [134]
;
Christine,Rappaport [134]
;
Daphne Geschwantler,Kaulich [135]
;
Georg,Pfeiler [136]
;
Muy-Kheng M,Tea [136]
;
Catherine M,Phelan [137]
;
Mark H,Greene [138]
;
Phuong L,Mai [139]
;
Gad,Rennert [140]
;
Anna Marie,Mulligan [141]
;
Gord,Glendon [142]
;
Sandrine,Tchatchou [143]
;
Irene L,Andrulis [144]
;
Amanda Ewart,Toland [145]
;
Anders,Bojesen [146]
;
Inge Sokilde,Pedersen [147]
;
Mads,Thomassen [148]
;
Uffe Birk,Jensen [149]
;
Yael,Laitman [150]
;
Johanna,Rantala [151]
;
Anna,von Wachenfeldt [152]
;
Hans,Ehrencrona [7]
;
Marie Stenmark,Askmalm [7]
;
Åke,Borg [7]
;
Karoline B,Kuchenbaecker [13]
;
Lesley,McGuffog [7]
;
Daniel,Barrowdale [153]
;
Sue,Healey [13]
;
Andrew,Lee [7]
;
Paul D P,Pharoah [154]
;
Georgia,Chenevix-Trench ;
KConFab Investigators ;
Antonis C,Antoniou ;
Eitan,Friedman
作者单位：
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy. paolo.peterlongo@ifom.eu eitan.friedman@sheba.health.gov.il feitan@post.tau.ac.il.
[1]
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[2]
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
[3]
Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany. Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany, on behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC).
[4]
Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada.
[5]
Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, United Kingdom.
[6]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
[7]
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[8]
Genomic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[9]
Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[10]
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
[11]
Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
[12]
Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia.
[13]
Department of Pathology, University of Otago, Christchurch, New Zealand.
[14]
Department of Biomedical Sciences and Medicine, Gambelas Campus, University of Algarve, Portugal.
[15]
Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy.
[16]
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
[17]
Department of Clinical Genetics, MUMC, Maastricht, the Netherlands.
[18]
Center for Clinical Cancer Genetics, Department of Medicine and Human Genetics, University of Chicago Medical Center, Chicago, Illinois.
[19]
Department of Medicine and Institute for Human Genetics, University of California, San Francisco, San Francisco, California.
[20]
Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadephia, Pennsylvania.
[21]
Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadephia, Pennsylvania.
[22]
University of Texas MD Anderson Cancer Center, Houston, Texas.
[23]
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
[24]
Departments of Pediatrics and Medicine, Columbia University, New York, New York.
[25]
Department of Genetics and Genomics at Case Western Reserve Medical School, Cleveland, Ohio.
[26]
Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia.
[27]
Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.
[28]
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.
[29]
Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology, and Transfusion Medicine Center, Dept. of Molecular and Regenerative Medicine; State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
[30]
Department of Genetics, University of Pretoria, Pretoria, South Africa.
[31]
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California.
[32]
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[33]
Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[34]
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[35]
Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
[36]
Molecular Genetics Laboratory, Department of Biochemistry, Cruces Hospital Barakaldo, 48903-Barakaldo-Bizkaia, Spain.
[37]
Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), Madrid, Spain.
[38]
Saint Alphonsus Regional Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California.
[39]
Clinical Cancer Genetics, City of Hope, Duarte, California.
[40]
Clinical Cancer Genetics, City of Hope, Duarte, California (for the City of Hope Clinical Cancer Genetics Community Research Network).
[41]
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.
[42]
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy.
[43]
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy. Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
[44]
Division of Experimental Oncology 1, CRO Aviano National Cancer Institute, Aviano (PN), Italy.
[45]
Department of Molecular Medicine, Sapienza University, Rome, Italy.
[46]
Unit of Medical Genetics, Department of Biomedical, Experimental, and Clinical Sciences, University of Florence, Florence, Italy.
[47]
Unit of Genetic Counseling, Medical Oncology Department, Istituto Nazionale Tumori Regina Elena, Rome, Italy.
[48]
UO Anatomia Patologica Ospedale di Circolo e Fondazione Macchi, Polo Universitario Varese, Italy.
[49]
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.
[50]
Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece.
[51]
Dana-Farber Cancer Institute, Boston, Massachuestts.
[52]
Clinical Genetics Department, St. Michael's Hospital, Bristol, United Kingdom.
[53]
Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom.
[54]
Cheshire & Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom.
[55]
Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
[56]
University of Southampton, Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom.
[57]
North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, United Kingdom.
[58]
Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom.
[59]
Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, United Kingdom.
[60]
Yorkshire Regional Genetics Service, Leeds, United Kingdom.
[61]
Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
[62]
Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom.
[63]
Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
[64]
North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
[65]
Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, Ireland. St. James's Hospital, Dublin, Ireland.
[66]
All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, United Kingdom.
[67]
South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom.
[68]
Centre for Cancer Research and Cell Biology, Queens University of Belfast, Department of Medical Genetics, Belfast HSC Trust, Belfast, United Kingdom.
[69]
West of Scotland Regional Genetics Service, Southern General Hospital, Glasgow, United Kingdom.
[70]
Medical Genetics Unit, St. George's, University of London, London, United Kingdom.
[71]
West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom.
[72]
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Missouri.
[73]
Center for Medical Genetics, Ghent University, Ghent, Belgium.
[74]
Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany.
[75]
Institute of Human Genetics, University Würzburg, Wurzburg, Germany.
[76]
University Heidelberg, Heidelberg, Germany.
[77]
Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany.
[78]
University Düsseldorf, Dusseldorf, Germany.
[79]
Hannover Medical School, Hanover, Germany.
[80]
Institute of Human Genetics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany.
[81]
Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
[82]
Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany. Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany.
[83]
Department of Gynaecology and Obstetrics, University Munich, Munich, Germany.
[84]
Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany.
[85]
Institute of Human Genetics, Charite Berlin, Germany.
[86]
Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany.
[87]
INSERM U946, Fondation Jean Dausset, Paris, France. Service de Génétique, Institut de Cancérologie Gustave Roussy, Villejuif, France.
[88]
Institut Curie, Department of Tumour Biology, Paris, France.
[89]
Centre René Gauducheau, Nantes, France.
[90]
Institut Curie, Department of Tumour Biology, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, France.
[91]
Institut Curie, Department of Tumour Biology, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, France. Institut Curie, INSERM U830, Paris, France.
[92]
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
[93]
Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France. Unité d'Oncogénétique, CRLCC Val d'Aurelle, Montpellier, France.
[94]
Unité d'Oncogénétique, CRLCC Val d'Aurelle, Montpellier, France.
[95]
Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France.
[96]
Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France.
[97]
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France. IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
[98]
Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France.
[99]
Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France. INSERM 896, CRCM Val d'Aurelle, Montpellier, France.
[100]
Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York.
[101]
Australia New Zealand Gynaecological Oncology Group (ANZGOG), Coordinating Centre, Camperdown, Australia.
[102]
Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, Illinois.
[103]
Ohio State University, Department of Obstetrics and Gynecology, Hilliard, Ohio.
[104]
Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
[105]
Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
[106]
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. University of Helsinki, Helsinki, Finland.
[107]
Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland.
[108]
Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
[109]
Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands.
[110]
Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands.
[111]
Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
[112]
Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.
[113]
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
[114]
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Erasmus University MC Cancer Institute, Rotterdam, the Netherlands.
[115]
Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands.
[116]
Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
[117]
Oncogenetics Group, University Hospital Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
[118]
Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
[119]
Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
[120]
Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain.
[121]
BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[122]
BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland.
[123]
Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Québec, Canada.
[124]
Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal. Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
[125]
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnessotta.
[126]
Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnessotta.
[127]
Health Sciences Research, Mayo Clinic, Scottsdale, Arizona.
[128]
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnessotta.
[129]
National Human Genome Research Institute, NIH, Bethesda, Maryland.
[130]
Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York.
[131]
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
[132]
Diagnostic Molecular Genetics Laboratory, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
[133]
Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
[134]
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
[135]
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland.
[136]
Clalit National Cancer Control Center, Haifa, Israel.
[137]
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.
[138]
Ontario Cancer Genetics Network: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
[139]
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
[140]
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.
[141]
Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
[142]
Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
[143]
Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
[144]
Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark.
[145]
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
[146]
Sheba Medical Center, Tel Aviv, Israel.
[147]
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
[148]
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
[149]
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden.
[150]
Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
[151]
Department of Oncology, Lund University, Lund, Sweden.
[152]
Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
[153]
Sheba Medical Center, Tel Aviv, Israel. paolo.peterlongo@ifom.eu eitan.friedman@sheba.health.gov.il feitan@post.tau.ac.il.
[154]
医学主题词
成年人(Adult);乳腺肿瘤(Breast Neoplasms);队列研究(Cohort Studies);女(雌)性(Female);基因, BRCA1(Genes, BRCA1);基因, BRCA2(Genes, BRCA2);人类(Humans);突变(Mutation);卵巢肿瘤(Ovarian Neoplasms);多态性, 单核苷酸(Polymorphism, Single Nucleotide);回顾性研究(Retrospective Studies);青年人(Young Adult)
DOI
10.1158/1055-9965.EPI-14-0532
PMID
25336561
发布时间
2024-11-26
- 浏览62
Cancer epidemiology, biomarkers & prevention
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