换一批
换一批Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
作者：
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);结合部位(Binding Sites);化学, 药物(Chemistry, Pharmaceutical);计算机模拟(Computer Simulation);结晶学, X线(Crystallography, X-Ray);脱氧胞苷(Deoxycytidine);脱氧胞苷激酶(Deoxycytidine Kinase);药物设计(Drug Design);女(雌)性(Female);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);微粒体(Microsomes);磷酰化(Phosphorylation);正电子发射断层显像术(Positron-Emission Tomography);前体细胞淋巴母细胞白血病淋巴瘤(Precursor Cell Lymphoblastic Leukemia-Lymphoma);蛋白激酶抑制剂(Protein Kinase Inhibitors);立体异构现象(Stereoisomerism);噻唑类(Thiazoles)
DOI
10.1021/jm501124j
PMID
25341194
发布时间
2022-03-21
- 浏览28
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
