The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.
作者:
主题词
主动转运, 细胞核(Active Transport, Cell Nucleus);衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);COS细胞(COS Cells);细胞核(Cell Nucleus);伴侣素包含蛋白TCP-1(Chaperonin Containing TCP-1);DNA结合蛋白质类(DNA-Binding Proteins);人类(Humans);MAP激酶激酶激酶1(MAP Kinase Kinase Kinase 1);模型, 分子(Models, Molecular);蛋白质结合(Protein Binding);蛋白质结构, 二级(Protein Structure, Secondary);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);构效关系(Structure-Activity Relationship)
DOI
10.1074/jbc.M114.586115
PMID
25342745
发布时间
2023-12-13
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