Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.

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第一作者： Shuwen,He

第一单位： Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

作者： Shuwen,He ^[1] ; Qingmei,Hong ^[1] ; Zhong,Lai ^[1] ; David X,Yang ^[1] ; Pauline C,Ting ^[1] ; Jeffrey T,Kuethe ^[1] ; Timothy A,Cernak ^[1] ; Kevin D,Dykstra ^[1] ; Donald M,Sperbeck ^[1] ; Zhicai,Wu ^[1] ; Yang,Yu ^[1] ; Ginger X,Yang ^[1] ; Tianying,Jian ^[1] ; Jian,Liu ^[1] ; Deodial,Guiadeen ^[1] ; Arto D,Krikorian ^[1] ; Lisa M,Sonatore ^[1] ; Judyann,Wiltsie ^[1] ; Jinqi,Liu ^[1] ; Judith N,Gorski ^[1] ; Christine C,Chung ^[1] ; Jack T,Gibson ^[1] ; JeanMarie,Lisnock ^[1] ; Jianying,Xiao ^[1] ; Michael,Wolff ^[1] ; Sharon X,Tong ^[1] ; Maria,Madeira ^[1] ; Bindhu V,Karanam ^[1] ; Dong-Ming,Shen ^[1] ; James M,Balkovec ^[1] ; Shirly,Pinto ^[1] ; Ravi P,Nargund ^[1] ; Robert J,DeVita ^[1]

作者单位： Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States. ^[1]

关键词 A2A receptor ACAT1 Ames test DGAT1 benzimidazole cyclohexanecarboxylic acid epimerization inhibitor lipid tolerance test metabolite skin

DOI 10.1021/ml5003426

PMID 25349648

发布时间 2021-10-21

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