Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture.
第一作者:
Majambu,Mbikay
第一单位:
Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada ; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada ; Laboratory of Functional Endoproteolysis, Clinical Research Institute of Montreal, Montreal, Quebec, Canada.
作者:
关键词
ABCA1, ATP-binding cassette transporter A1ApoB, apolipoprotein BCholesterolHMGCoAR, 3-hydroxy-3-methylglutaryl-CoA reductaseHepatocytesLDL-C, low-density lipoprotein-cholesterolLDLR, low-density lipoprotein receptorLow-density lipoprotein receptorPCSK9, proprotein convertase subtilisin/kexin 9Proprotein convertaseQ3G, quercetin-3-β-d-glucosideQuercetinSREBP-2, sterol regulatory element-binding protein 2SortilinTGN, trans Golgi network
DOI
10.1016/j.fob.2014.08.003
PMID
25349780
发布时间
2021-10-21
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FEBS open bio
755-62页
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