换一批Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
第一作者：
Jodie N,Painter
第一单位：
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
作者：
Jodie N,Painter [1]
;
Tracy A,O'Mara [1]
;
Jyotsna,Batra [2]
;
Timothy,Cheng [3]
;
Felicity A,Lose [1]
;
Joe,Dennis [4]
;
Kyriaki,Michailidou [4]
;
Jonathan P,Tyrer [5]
;
Shahana,Ahmed [5]
;
Kaltin,Ferguson [1]
;
Catherine S,Healey [5]
;
Susanne,Kaufmann [1]
;
Kristine M,Hillman [1]
;
Carina,Walpole [2]
;
Leire,Moya [2]
;
Pamela,Pollock [6]
;
Angela,Jones [3]
;
Kimberley,Howarth [3]
;
Lynn,Martin [3]
;
Maggie,Gorman [3]
;
Shirley,Hodgson [7]
;
National Study of Endometrial Cancer Genetics Group (NSECG) [8]
;
CHIBCHA Consortium [9]
;
Ma Magdalena Echeverry,De Polanco [10]
;
Monica,Sans [11]
;
Angel,Carracedo [12]
;
Sergi,Castellvi-Bel [13]
;
Augusto,Rojas-Martinez [14]
;
Erika,Santos [15]
;
Manuel R,Teixeira [16]
;
Luis,Carvajal-Carmona [16]
;
Xiao-Ou,Shu [16]
;
Jirong,Long [17]
;
Wei,Zheng [1]
;
Yong-Bing,Xiang [1]
;
Australian National Endometrial Cancer Study Group (ANECS) [18]
;
Grant W,Montgomery [19]
;
Penelope M,Webb [20]
;
Rodney J,Scott [21]
;
Mark,McEvoy [1]
;
John,Attia [1]
;
Elizabeth,Holliday [1]
;
Nicholas G,Martin [22]
;
Dale R,Nyholt [23]
;
Anjali K,Henders [23]
;
Peter A,Fasching [23]
;
Alexander,Hein [24]
;
Matthias W,Beckmann [25]
;
Stefan P,Renner [26]
;
Thilo,Dörk [26]
;
Peter,Hillemanns [27]
;
Matthias,Dürst [28]
;
Ingo,Runnebaum [28]
;
Diether,Lambrechts [28]
;
Lieve,Coenegrachts [29]
;
Stefanie,Schrauwen [29]
;
Frederic,Amant [30]
;
Boris,Winterhoff [29]
;
Sean C,Dowdy [31]
;
Ellen L,Goode [31]
;
Attila,Teoman [31]
;
Helga B,Salvesen [31]
;
Jone,Trovik [32]
;
Tormund S,Njolstad [33]
;
Henrica M J,Werner [33]
;
Katie,Ashton [34]
;
Tony,Proietto [34]
;
Geoffrey,Otton [35]
;
Gerasimos,Tzortzatos [36]
;
Miriam,Mints [36]
;
Emma,Tham [37]
;
RENDOCAS [37]
;
Per,Hall [38]
;
Kamila,Czene [39]
;
Jianjun,Liu [40]
;
Jingmei,Li [23]
;
John L,Hopper [41]
;
Melissa C,Southey [42]
;
Australian Ovarian Cancer Study (AOCS) [43]
;
Arif B,Ekici [44]
;
Matthias,Ruebner [45]
;
Nicola,Johnson [45]
;
Julian,Peto [46]
;
Barbara,Burwinkel [47]
;
Frederik,Marme [35]
;
Hermann,Brenner [48]
;
Aida K,Dieffenbach [48]
;
Alfons,Meindl [49]
;
Hiltrud,Brauch [50]
;
GENICA Network [51]
;
Annika,Lindblom [30]
;
Jeroen,Depreeuw [52]
;
Matthieu,Moisse [53]
;
Jenny,Chang-Claude [51]
;
Anja,Rudolph [54]
;
Fergus J,Couch [55]
;
Janet E,Olson [56]
;
Graham G,Giles [57]
;
Fiona,Bruinsma [58]
;
Julie M,Cunningham [59]
;
Brooke L,Fridley [4]
;
Anne-Lise,Børresen-Dale [4]
;
Vessela N,Kristensen [60]
;
Angela,Cox [61]
;
Anthony J,Swerdlow [5]
;
Nicholas,Orr [1]
;
Manjeet K,Bolla [5]
;
Qin,Wang [5]
;
Rachel Palmieri,Weber [3]
;
Zhihua,Chen [62]
;
Mitul,Shah [1]
;
Juliet D,French [5]
;
Paul D P,Pharoah [63]
;
Alison M,Dunning ;
Ian,Tomlinson ;
Douglas F,Easton ;
Stacey L,Edwards ;
Deborah J,Thompson ;
Amanda B,Spurdle
作者单位：
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
[1]
Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, and School of Biomedical Science and.
[2]
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
[3]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and.
[4]
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
[5]
Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia.
[6]
Department of Clinical Genetics, St George's Hospital Medical School, London, UK.
[7]
Grupo de Investigación Citogenética, Filogenia y Evolución de Poblaciones, Universidad del Tolima, Ibagué, Tolima, Colombia.
[8]
Department of Biological Anthropology, College of Humanities and Educational Sciences, University of the Republic, Magallanes, Montevideo, Uruguay.
[9]
Grupo de Medicina Xenómica, Fundación Galega de Medicina Xenómica (SERGAS) and CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain, Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, KSA.
[10]
Genetic Predisposition to Colorectal Cancer Group, Gastrointestinal & Pancreatic Oncology Team, IDIBAPS/CIBERehd/Hospital Clínic, Centre Esther Koplowitz (CEK), Barcelona, Spain.
[11]
Universidad Autónoma de Nuevo León, Pedro de Alba s/n, San Nicolás de Los Garza, Nuevo León, Mexico.
[12]
Hospital A.C. Camargo, São Paulo, Brazil.
[13]
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal, Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
[14]
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, Grupo de Investigación Citogenética, Filogenia y Evolución de Poblaciones, Universidad del Tolima, Ibagué, Tolima, Colombia, Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
[15]
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
[16]
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
[17]
Hunter Medical Research Institute and, Hunter Area Pathology Service, John Hunter Hospital, Newcastle, NSW, Australia, Centre for Information Based Medicine and School of Biomedical Science and Pharmacy.
[18]
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health.
[19]
Hunter Medical Research Institute and, Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health.
[20]
Hunter Medical Research Institute and, Centre for Information Based Medicine and School of Medicine and Public Health.
[21]
Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
[22]
University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
[23]
Gynaecology Research Unit and.
[24]
Clinics of Gynaecology and Obstetrics, Hannover Medical School, Hannover, Germany.
[25]
Dept. of Gynaecology, Friedrich Schiller University Jena, Jena, Germany.
[26]
Vesalius Research Center, VIB, Leuven, Belgium, Department of Oncology, Laboratory for Translational Genetics.
[27]
Division of Gynaecological Oncology, Department of Oncology, University Hospital Leuven, KU Leuven, Belgium.
[28]
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology.
[29]
Division of Epidemiology, Department of Health Science Research and.
[30]
Department of Clinical Science, Centre for Cancerbiomarkers, The University of Bergen, Norway, Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
[31]
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, NSW, Australia, Faculty of Health, Centre for Information Based Medicine and the Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy and.
[32]
Faculty of Health, School of Medicine and Public Health, University of Newcastle, NSW, Australia.
[33]
Department of Women's and Children's Health.
[34]
Department of Molecular Medicine and Surgery and.
[35]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
[36]
Human Genetics, Genome Institute of Singapore, Singapore.
[37]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health and.
[38]
Department of Pathology, Genetic Epidemiology Laboratory, The University of Melbourne, Melbourne, VIC, Australia.
[39]
Institute of Human Genetics, University Hospital, Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
[40]
Breakthrough Breast Cancer Research Centre.
[41]
London School of Hygiene and Tropical Medicine, London, UK.
[42]
Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, Molecular Epidemiology, C080.
[43]
Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
[44]
Division of Clinical Epidemiology and Aging Research, German Cancer Consortium (DKTK), Heidelberg, Germany.
[45]
Division of Tumor Genetics, Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany.
[46]
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology Stuttgart, University of Tuebingen, Germany.
[47]
Vesalius Research Center, VIB, Leuven, Belgium.
[48]
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[49]
Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
[50]
Departments of Laboratory Medicine and Pathology, and Health Science Research, Mayo Clinic, Rochester, MN, USA.
[51]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health and Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
[52]
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia.
[53]
Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA.
[54]
Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway, Faculty of Medicine, The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.
[55]
Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway, Faculty of Medicine, The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Division of Medicine, Department of Clinical Molecular Oncology, Akershus University Hospital, Ahus, Norway.
[56]
Department of Oncology, Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK.
[57]
Division of Genetics and Epidemiology and, Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
[58]
Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
[59]
Department of Community and Family Medicine, Duke University School of Medicine, Durham, NC, USA.
[60]
Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
[61]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
[62]
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia, amanda.spurdle@qimrberghofer.edu.au.
[63]
医学主题词
等位基因(Alleles);病例对照研究(Case-Control Studies);细胞系, 肿瘤(Cell Line, Tumor);染色体图(Chromosome Mapping);计算生物学(Computational Biology);数据库, 遗传学(Databases, Genetic);子宫内膜肿瘤(Endometrial Neoplasms);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);基因座(Genetic Loci);遗传变异(Genetic Variation);全基因组关联研究(Genome-Wide Association Study);基因型(Genotype);单倍型(Haplotypes);肝细胞核因子1β(Hepatocyte Nuclear Factor 1-beta);人类(Humans);连锁不平衡(Linkage Disequilibrium);多态性, 单核苷酸(Polymorphism, Single Nucleotide);启动区, 遗传(Promoter Regions, Genetic);RNA, 信使(RNA, Messenger);危险因素(Risk Factors)
DOI
10.1093/hmg/ddu552
PMID
25378557
发布时间
2025-07-31
- 浏览29
Human molecular genetics
Human molecular genetics
1478-92页
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