Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage.-论文-万方医学网

作者： Rebecca M,Green ^[1] ; Weiguo,Feng ^[1] ; Tzulip,Phang ^[2] ; Jennifer L,Fish ^[3] ; Hong,Li ^[1] ; Richard A,Spritz ^[4] ; Ralph S,Marcucio ^[3] ; Joan,Hooper ^[5] ; Heather,Jamniczky ^[6] ; Benedikt,Hallgrímsson ^[7] ; Trevor,Williams ^[8]

作者单位： Department of Craniofacial Biology, University of Colorado Denver, 12801 East 17th Avenue, Aurora, CO 80045, USA. ^[1] Department of Pharmacology, University of Colorado Denver, 12801 East 17th Avenue, Aurora, CO 80045, USA. ^[2] University of California San Francisco, Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, San Francisco, CA 94110, USA. ^[3] Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, 12800 East 17th Avenue, Aurora, CO 80045, USA. ^[4] Department of Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, Aurora, CO 80045, USA. ^[5] McCaig Institute for Bone and Joint Health, Department of Cell Biology & Anatomy, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N3Z6, Canada. ^[6] McCaig Institute for Bone and Joint Health, Department of Cell Biology & Anatomy, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N3Z6, Canada. Alberta Children's Hospital Research Institute, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N3Z6, Canada. ^[7] Department of Craniofacial Biology, University of Colorado Denver, 12801 East 17th Avenue, Aurora, CO 80045, USA. Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, 12800 East 17th Avenue, Aurora, CO 80045, USA. Department of Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, Aurora, CO 80045, USA. Trevor.Williams@ucdenver.edu. ^[8]

主题词等位基因(Alleles);动物(Animals);细胞凋亡(Apoptosis);骨和骨组织(Bone and Bones);软骨(Cartilage);细胞增殖(Cell Proliferation);唇裂(Cleft Lip);腭裂(Cleft Palate);疾病模型, 动物(Disease Models, Animal);面部(Face);女(雌)性(Female);成纤维细胞生长因子8(Fibroblast Growth Factor 8);基因剂量(Gene Dosage);基因表达谱(Gene Expression Profiling);基因型(Genotype);人类(Humans);原位杂交(In Situ Hybridization);小鼠(Mice);突变(Mutation);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);表型(Phenotype);信号传导(Signal Transduction);转录因子AP-2(Transcription Factor AP-2)

DOI 10.1242/dmm.017616

PMID 25381013

发布时间 2025-01-04

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Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage.

Disease models & mechanisms

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Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage.

Disease models & mechanisms

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Disease models & mechanisms

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