换一批Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.
第一作者：
Emily J,Hanan
第一单位：
Departments of †Discovery Chemistry, ‡Structural Biology, §Drug Metabolism and Pharmacokinetics, ∥Biochemical and Cellular Pharmacology, ⊥Molecular Oncology, and #Protein Expression, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
作者：
医学主题词
氨基酸取代(Amino Acid Substitution);氨基吡啶类(Aminopyridines);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);结晶学, X线(Crystallography, X-Ray);抗药性, 肿瘤(Drug Resistance, Neoplasm);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);肺肿瘤(Lung Neoplasms);甲硫氨酸(Methionine);突变(Mutation);蛋白激酶抑制剂(Protein Kinase Inhibitors);苏氨酸(Threonine)
DOI
10.1021/jm501578n
PMID
25383627
发布时间
2018-12-02
基金项目
Howard Hughes Medical Institute/United States
- 浏览70
Journal of medicinal chemistry
10176-91页
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