换一批
换一批The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
作者：
主题词
动物(Animals);结合部位(Binding Sites);细胞系(Cell Line);细胞增殖(Cell Proliferation);疾病模型, 动物(Disease Models, Animal);药物评价, 临床前(Drug Evaluation, Preclinical);叉头转录因子类(Forkhead Transcription Factors);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);神经保护药(Neuroprotective Agents);帕金森病(Parkinson Disease);蛋白质结合(Protein Binding);蛋白质结构, 三级(Protein Structure, Tertiary);嘧啶酮类(Pyrimidinones);大鼠(Rats);抗衰老酶2(Sirtuin 2);构效关系(Structure-Activity Relationship);噻吩类(Thiophenes)
DOI
10.1002/cmdc.201402431
PMID
25395356
发布时间
2022-03-16
- 浏览169
ChemMedChem
69-82页
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