换一批Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.
第一作者：
Kevin C,Conlon
第一单位：
Kevin C. Conlon, Steven A. Rosenberg, Antonio Tito Fojo, John C. Morris, Thomas A. Fleisher, Sigrid P. Dubois, Liyanage P. Perera, Donn M. Stewart, Carolyn K. Goldman, Bonita R. Bryant, Jean M. Decker, Jing Chen, Tat'Yana A. Worthy, William D. Figg Sr, Cody J. Peer, and Thomas A. Waldmann, National Cancer Institute; Enrico Lugli, Hugh C. Welles, Michael C. Sneller, H. Clifford Lane, and Mario Roederer, National Institute of Allergy and Infectious Diseases, Bethesda; Jason L. Yovandich and Stephen P. Creekmore, National Cancer Institute, Frederick, MD; and Hugh C. Welles, Columbian College of Arts and Sciences, George Washington University, Washington, DC.
作者：
医学主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);曲线下面积(Area Under Curve);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);用药计划表(Drug Administration Schedule);女(雌)性(Female);发热(Fever);人类(Humans);输注, 静脉内(Infusions, Intravenous);白细胞介素15(Interleukin-15);杀伤细胞, 天然(Killer Cells, Natural);淋巴细胞活化(Lymphocyte Activation);男(雄)性(Male);代谢清除率(Metabolic Clearance Rate);中年人(Middle Aged);恶心(Nausea);肿瘤转移(Neoplasm Metastasis);肿瘤(Neoplasms);中性粒细胞减少(Neutropenia);重组蛋白质类(Recombinant Proteins);治疗结果(Treatment Outcome);青年人(Young Adult)
DOI
10.1200/JCO.2014.57.3329
PMID
25403209
发布时间
2022-03-21
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