Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain.

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作者： Yi,Zou ^[1] ; Wanxiang,Jiang ^[1] ; Jianqing,Wang ^[1] ; Zhongping,Li ^[1] ; Junyan,Zhang ^[2] ; Jicheng,Bu ^[1] ; Jia,Zou ^[1] ; Liang,Zhou ^[1] ; Shouyang,Yu ^[1] ; Yiyuan,Cui ^[1] ; Weiwei,Yang ^[1] ; Liping,Luo ^[2] ; Qing R,Lu ^[3] ; Yanhui,Liu ^[4] ; Mina,Chen ^[1] ; Paul F,Worley ^[5] ; Bo,Xiao ^[6]

作者单位： Neuroscience and Metabolism Research, The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041 Chengdu, P.R. China. ^[1] Neuroscience and Metabolism Research, The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041 Chengdu, P.R. China, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. ^[2] Department of Pediatrics, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, and. ^[3] Department of Neurosurgery, West China Hospital, Sichuan University, 610041 Chengdu, P.R. China. ^[4] The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, bxiao365@yahoo.com pworley@jhmi.edu. ^[5] Neuroscience and Metabolism Research, The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041 Chengdu, P.R. China, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Neurosurgery, West China Hospital, Sichuan University, 610041 Chengdu, P.R. China bxiao365@yahoo.com pworley@jhmi.edu. ^[6]

关键词 OPC Rheb1 differentiation mTORC1 myelination