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首页> PloS one> EGb761 provides a protective effect against Aβ1-42 oligomer-induced cell damage and blood-brain barrier disruption in an in vitro bEnd.3 endothelial model.

EGb761 provides a protective effect against Aβ1-42 oligomer-induced cell damage and blood-brain barrier disruption in an in vitro bEnd.3 endothelial model.

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作者： Wen-bin,Wan ^[1] ; Lan,Cao ^[2] ; Lu-mei,Liu ^[3] ; Bill,Kalionis ^[4] ; Chuan,Chen ^[5] ; Xian-tao,Tai ^[6] ; Ya-ming,Li ^[3] ; Shi-jin,Xia ^[7]

作者单位： Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China. ^[1] State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, China. ^[2] Geriatrics Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai, China. ^[3] Department of Perinatal Medicine Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, VIC, Australia. ^[4] Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China. ^[5] School of Acupuncture, Massage and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, China. ^[6] Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai, China. ^[7]

主题词淀粉样β肽类(Amyloid beta-Peptides);细胞凋亡(Apoptosis);血脑屏障(Blood-Brain Barrier);细胞系, 转化(Cell Line, Transformed);内皮细胞(Endothelial Cells);基因表达(Gene Expression);银杏(Ginkgo biloba);人类(Humans);模型, 生物学(Models, Biological);脑代谢改善药(Nootropic Agents);肽碎片(Peptide Fragments);植物提取物(Plant Extracts);活性氧(Reactive Oxygen Species);受体, 免疫(Receptors, Immunologic);紧密连接部(Tight Junctions)

DOI 10.1371/journal.pone.0113126

PMID 25426944

发布时间 2021-12-03

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PloS one

PloS one

2014年9卷11期

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