换一批Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein.
第一作者：
François,Curtin
第一单位：
a GeNeuro SA; Plan-les-Ouates/Geneva , Switzerland.
作者：
关键词
ADCC, antibody-dependent cell-mediated cytotoxicityAE, adverse eventsAUC, area under the curveBLAST, Basic Local Alignment Search ToolCDC, complement-dependent cytotoxicityCDR, complementarity-determining regionsCmax, maximal concentrationCmin, minimal concentrationHERV-WHERV-W, human endogenous retrovirus type WHLA, human leukocyte antigenMOG, myelin oligodendrocyte glycoproteinMS, multiple sclerosisMSRVMSRV, multiple sclerosis associated retrovirusMSRV-Env, multiple sclerosis associated retrovirus envelope proteinPBMC, peripheral blood mononuclear cellSAE, serious adverse eventSU, surface domainSyncytinTLR4, Toll-like receptor 4ch-GNbAC1, chimeric version of mAb GNbAC1drug safetyhuman endogenous retrovirusmAb, monoclonal antibodymonoclonal antibodymu-GNbAC1, murine version of mAb GNbAC1multiple sclerosisneurotoxicitytoxicology
医学主题词
动物(Animals);抗体特异性(Antibody Specificity);脑脊髓炎, 自身免疫性, 实验性(Encephalomyelitis, Autoimmune, Experimental);内源性逆转录病毒(Endogenous Retroviruses);女(雌)性(Female);基因产物, env(Gene Products, env);HEK293细胞(HEK293 Cells);人类(Humans);免疫球蛋白G(Immunoglobulin G);男(雄)性(Male);小鼠(Mice);多发性硬化(Multiple Sclerosis)
DOI
10.4161/19420862.2014.985021
PMID
25427053
发布时间
2024-05-20
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