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Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.

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作者单位: Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. [1] Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. [2] Department of Immunology, Institute of Cell Biology, and German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Partner Site Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany. [3] Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland. [4] 1] Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA [2] Department of Medicine, Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. [5] The Genome Institute, Washington University School of Medicine, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA. [6] ISA Therapeutics B.V., 2333 CH Leiden, The Netherlands. [7] Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. [8] Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, USA. [9] Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. [10] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. [11] Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. [12] 1] Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland [2] Faculty of Science, University of Zurich, Zurich, 8093 Zurich, Switzerland. [13] 1] ISA Therapeutics B.V., 2333 CH Leiden, The Netherlands [2] Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333ZA Leiden, The Netherlands. [14] 1] The Genome Institute, Washington University School of Medicine, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA [2] Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. [15]
DOI 10.1038/nature13988
PMID 25428507
发布时间 2024-06-10
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