The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability.

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作者： Kun,Gao ^[1] ; Jian,An ^[2] ; Yuanyuan,Zhang ^[1] ; Xiaofeng,Jin ^[1] ; Jian,Ma ^[3] ; Jingtao,Peng ^[3] ; Yan,Tang ^[1] ; Long,Yu ^[4] ; Pingzhao,Zhang ^[5] ; Chenji,Wang ^[6]

作者单位： State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, PR China. ^[1] Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, PR China. ^[2] Department of Urology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, PR China. ^[3] State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, PR China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PR China. ^[4] State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, PR China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PR China. Electronic address: pzzhang@fudan.edu.cn. ^[5] State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, PR China. Electronic address: chenjiwang@fudan.edu.cn. ^[6]

关键词 Apoptosis PPXY motif Proteasomal degradation Ubiquitination WW domain