换一批Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients.
第一作者：
Michaël,Van Damme
第一单位：
a Laboratory of Clinical Cell Therapy; Faculty of Medicine; Institut Jules Bordet ; Université Libre de Bruxelles (ULB) ; Brussels , Belgium.
作者：
关键词
B2M, Beta-2-microglobulinBCR, B cell receptorCLL, Chronic lymphocytic leukemiaFCR Fludarabine-cyclophosphamide-rituximabHDACHDAC, Histone deacetylaseHDACi, HDAC inhibitorHR Hazard ratioIgHV, Immunoglobulin heavy-chain variable-regionLDT, Lymphocyte doubling timeLPL, Lipoprotein lipaseMSC, Mesenchymal stromal cellNF-κB, Nuclear factor κBOS, Overall survivalSAHA, Suberoylanilide hydroxamic acidSIRT, SirtuinSirtuinTFS, Treatment-free survivalVPA, Valproic acidZAP70, Zeta-chain-associated protein kinase 70chronic lymphocytic leukemiaenzymatic activityprognosissCD23, Soluble CD23
医学主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);B-淋巴细胞(B-Lymphocytes);病例对照研究(Case-Control Studies);组蛋白脱乙酰基酶类(Histone Deacetylases);组蛋白类(Histones);人类(Humans);白血病, 淋巴细胞, 慢性, B细胞(Leukemia, Lymphocytic, Chronic, B-Cell);中年人(Middle Aged);预后(Prognosis);比例危险度模型(Proportional Hazards Models);肿瘤细胞, 培养的(Tumor Cells, Cultured)
DOI
10.4161/15592294.2014.969628
PMID
25437053
发布时间
2018-11-13
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Epigenetics
1374-81页
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