Monitoring liver macrophages using nanobodies targeting Vsig4: concanavalin A induced acute hepatitis as paradigm.

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作者： Fang,Zheng ^[1] ; Nick,Devoogdt ^[2] ; Amanda,Sparkes ^[3] ; Yannick,Morias ^[3] ; Chloé,Abels ^[3] ; Benoit,Stijlemans ^[3] ; Tony,Lahoutte ^[4] ; Serge,Muyldermans ^[5] ; Patrick,De Baetselier ^[3] ; Steve,Schoonooghe ^[3] ; Alain,Beschin ^[3] ; Geert,Raes ^[6]

作者单位： Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium; Department of Biochemistry and Molecular Biology, Health Science Center, Xi'an Jiaotong University, Xi'an, China. ^[1] Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; In Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, Belgium. ^[2] Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium. ^[3] In Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, Belgium; Department of Nuclear Medicine, UZ Brussel, Vrije Universtiteit Brussel, Brussels, Belgium. ^[4] Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; VIB Structural Biology Research Center, Vrije Universiteit Brussel, Brussels, Belgium. ^[5] Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium. Electronic address: Geert.Raes@vib-vub.be. ^[6]

关键词 Complement receptor of the Ig superfamily (CRIg)Concanavalin A (ConA)Hepatitis Kupffer cells Nanobody SPECT/μCT V-set and immunoglobulin domain-containing 4 (Vsig4)