Polygonatum odoratum lectin induces apoptosis and autophagy via targeting EGFR-mediated Ras-Raf-MEK-ERK pathway in human MCF-7 breast cancer cells.

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第一作者： Liang,Ouyang

第一单位： State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

作者： Liang,Ouyang ^[1] ; Yi,Chen ^[1] ; Xiao-yan,Wang ^[2] ; Rui-feng,Lu ^[3] ; Shou-yue,Zhang ^[1] ; Mao,Tian ^[1] ; Tao,Xie ^[1] ; Bo,Liu ^[4] ; Gu,He ^[5]

作者单位： State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. ^[1] Analytical and Testing Center, Sichuan University, Chengdu 610064, China. ^[2] Department of Pediatrics, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610064, China. ^[3] State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: liubo2400@163.com. ^[4] State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: heguscu@163.com. ^[5]

关键词 Apoptosis Autophagy Epidermal growth factor receptor (EGFR)MCF-7 cell Polygonatum odoratum lectin (POL)

主题词细胞凋亡(Apoptosis);自噬(Autophagy);人类(Humans);外源凝集素类(Lectins);MAP激酶信号系统(MAP Kinase Signaling System);线粒体(Mitochondria);黄精属(Polygonatum)

DOI 10.1016/j.phymed.2014.08.002

PMID 25442274

发布时间 2022-04-08

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