Ion milling coupled field emission scanning electron microscopy reveals current misunderstanding of morphology of polymeric nanoparticles.

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第一作者： Donny,Francis

第一单位： Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.

作者： Donny,Francis ^[1] ; Samiha,Mouftah ^[1] ; Robert,Steffen ^[2] ; Arnaud,Beduneau ^[3] ; Yann,Pellequer ^[3] ; Alf,Lamprecht ^[4]

作者单位： Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany. ^[1] Nanotechnology Equipment Department, Hitachi High-Technologies Europe GmbH, Krefeld, Germany. ^[2] Laboratory of Pharmaceutical Engineering (EA4267), University of Franche-Comté, Besançon, France. ^[3] Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany; Laboratory of Pharmaceutical Engineering (EA4267), University of Franche-Comté, Besançon, France. Electronic address: alf.lamprecht@uni-bonn.de. ^[4]

关键词 Double emulsion technique Ion milling Nanoparticle morphology Nanoparticles Polyester Protein adsorption Protein encapsulation

主题词药物释放系统(Drug Delivery Systems);乳状剂(Emulsions);显微镜检查, 电子, 扫描(Microscopy, Electron, Scanning);纳米粒子(Nanoparticles);粒子大小(Particle Size);聚合物(Polymers);表面特性(Surface Properties)

DOI 10.1016/j.ejpb.2014.11.008

PMID 25448070

发布时间 2015-03-09

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