Antiplatelet action of indirubin-3'-monoxime through suppression of glycoprotein VI-mediated signal transduction: a possible role for ERK signaling in platelets.-论文-万方医学网

作者： Jung-Jin,Lee ^[1] ; Joo-Hui,Han ^[2] ; Sang-Hyuk,Jung ^[3] ; Sang-Gil,Lee ^[3] ; In-Su,Kim ^[3] ; Nguyen Manh,Cuong ^[4] ; Tran Thu,Huong ^[4] ; Pham Ngoc,Khanh ^[4] ; Young Ho,Kim ^[5] ; Yeo-Pyo,Yun ^[6] ; Jin Yeul,Ma ^[7] ; Chang-Seon,Myung ^[8]

作者单位： Department of Pharmacology, Chungnam National University College of Pharmacy, Daejeon 305-764, Republic of Korea; Korean Medicine (KM)-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea. ^[1] Department of Pharmacology, Chungnam National University College of Pharmacy, Daejeon 305-764, Republic of Korea; Institute of Drug Research & Development, Chungnam National University, Daejeon 305-764, Republic of Korea. ^[2] Department of Pharmacology, Chungnam National University College of Pharmacy, Daejeon 305-764, Republic of Korea. ^[3] Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Caugiay, Hanoi, Viet Nam. ^[4] Institute of Drug Research & Development, Chungnam National University, Daejeon 305-764, Republic of Korea; Department of Natural Product Chemistry, Chungnam National University College of Pharmacy, Daejeon 305-764, Republic of Korea. ^[5] College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361-763, Republic of Korea. ^[6] Korean Medicine (KM)-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea. ^[7] Department of Pharmacology, Chungnam National University College of Pharmacy, Daejeon 305-764, Republic of Korea; Institute of Drug Research & Development, Chungnam National University, Daejeon 305-764, Republic of Korea. Electronic address: cm8r@cnu.ac.kr. ^[8]

主题词动物(Animals);血小板(Blood Platelets);胶原(Collagen);响尾蛇毒液类(Crotalid Venoms);糖原合成酶激酶3(Glycogen Synthase Kinase 3);吲哚类(Indoles);外源凝集素类, C型(Lectins, C-Type);MAP激酶信号系统(MAP Kinase Signaling System);男(雄)性(Male);肟类(Oximes);佛波醇酯类(Phorbol Esters);磷脂酶Cγ(Phospholipase C gamma);磷酰化(Phosphorylation);血小板活化(Platelet Activation);血小板聚集(Platelet Aggregation);血小板膜糖蛋白类(Platelet Membrane Glycoproteins);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);兔(Rabbits);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 胶原(Receptors, Collagen);信号传导(Signal Transduction)

DOI 10.1016/j.vph.2014.10.005

PMID 25451564

发布时间 2016-11-25

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Antiplatelet action of indirubin-3'-monoxime through suppression of glycoprotein VI-mediated signal transduction: a possible role for ERK signaling in platelets.

Vascular pharmacology

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Vascular pharmacology

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Antiplatelet action of indirubin-3'-monoxime through suppression of glycoprotein VI-mediated signal transduction: a possible role for ERK signaling in platelets.

Vascular pharmacology

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Vascular pharmacology

相关期刊

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