Cidofovir and brincidofovir reduce the pathology caused by systemic infection with human type 5 adenovirus in immunosuppressed Syrian hamsters, while ribavirin is largely ineffective in this model.
第一作者:
Ann E,Tollefson
第一单位:
Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Blvd., St. Louis, MO 63104, USA.
作者:
主题词
腺病毒科感染(Adenoviridae Infections);腺病毒, 人(Adenoviruses, Human);丙氨酸转氨酶(Alanine Transaminase);动物(Animals);体重(Body Weight);细胞系(Cell Line);胞嘧啶(Cytosine);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);人类(Humans);免疫减弱宿主(Immunocompromised Host);肝(Liver);金仓鼠(Mesocricetus);利巴韦林(Ribavirin);存活率分析(Survival Analysis);治疗结果(Treatment Outcome);病毒载量(Viral Load)
DOI
10.1016/j.antiviral.2014.10.005
PMID
25453340
发布时间
2020-03-16
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Antiviral research
38-46页
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