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首页> Journal of pharmaceutical and biomedical analysis> An immunodepletion procedure advances free angiopoietin-2 determination in human plasma samples during anti-cancer therapy with bispecific anti-Ang2/VEGF CrossMab.

An immunodepletion procedure advances free angiopoietin-2 determination in human plasma samples during anti-cancer therapy with bispecific anti-Ang2/VEGF CrossMab.

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作者： Kay,Stubenrauch ^[1] ; Uwe,Wessels ^[2] ; Ulrich,Essig ^[3] ; Rudolf,Vogel ^[3] ; Harald,Waltenberger ^[4] ; Andre,Hansbauer ^[4] ; Astrid,Koehler ^[5] ; Julia,Heinrich ^[2]

作者单位： Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Large Molecule Bioanalytical Research & Assay Development, Roche Innovation Center Penzberg, Nonnenwald 2, 82377 Penzberg, Germany. Electronic address: kay-gunnar.stubenrauch@roche.com. ^[1] Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Large Molecule Bioanalytical Research & Assay Development, Roche Innovation Center Penzberg, Nonnenwald 2, 82377 Penzberg, Germany. ^[2] Roche Diagnostics GmbH, Roche Professional Diagnostic R&D, Nonnenwald 2, D-82377 Penzberg, Germany. ^[3] Microcoat Biotechnologie GmbH, Am Neuland 3, 82347 Bernried am Starnberger See, Germany. ^[4] Roche Pharma Research and Early Development (pRED), Oncology, Translational Medicine Group, Roche Innovation Center Penzberg, Nonnenwald 2, 82377 Penzberg, Germany. ^[5]

关键词 Anti-idiotypic monoclonal antibody Bispecific therapeutic antibody Free target quantification Immunodepletion Total target level

主题词血管生成素2(Angiopoietin-2);动物(Animals);抗体, 双特异性(Antibodies, Bispecific);抗体, 单克隆(Antibodies, Monoclonal);抗肿瘤药(Antineoplastic Agents);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);人类(Humans);免疫球蛋白G(Immunoglobulin G);成束猴(Macaca fascicularis);血管内皮生长因子A(Vascular Endothelial Growth Factor A)

DOI 10.1016/j.jpba.2014.10.005

PMID 25459946

发布时间 2015-02-02

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Journal of pharmaceutical and biomedical analysis

459-67页

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