Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context.

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作者： E Dinant,Kroese ^[1] ; Sieto,Bosgra ^[2] ; Harrie E,Buist ^[2] ; Geertje,Lewin ^[3] ; Sander C,van der Linden ^[4] ; Hai-yen,Man ^[4] ; Aldert H,Piersma ^[5] ; Emiel,Rorije ^[6] ; Sjors H W,Schulpen ^[7] ; Michael,Schwarz ^[8] ; Frederik,Uibel ^[8] ; Barbara M A,van Vugt-Lussenburg ^[4] ; Andre P M,Wolterbeek ^[2] ; Bart,van der Burg ^[4]

作者单位： TNO, Zeist, The Netherlands. Electronic address: dinant.kroese@tno.nl. ^[1] TNO, Zeist, The Netherlands. ^[2] Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany. ^[3] BioDetection Systems BV, Amsterdam, The Netherlands. ^[4] Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. ^[5] Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. ^[6] Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. ^[7] Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Toxicology, University of Tübingen, Tübingen, Germany. ^[8]

关键词 Alternative model CALUX Developmental toxicity Embryonic stem cell test Grouping ReProGlo Read across Zebrafish embryotoxicity assay