换一批Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
第一作者：
Timothy D,Cushing
第一单位：
Department of Therapeutic Discovery, ‡Department of Pharmacokinetics and Drug Metabolism, and §Department of Pharmaceutics Research and Development, Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
作者：
医学主题词
腺苷(Adenosine);动物(Animals);自身免疫疾病(Autoimmune Diseases);细胞, 培养的(Cells, Cultured);I类磷脂酰肌醇3-激酶类(Class I Phosphatidylinositol 3-Kinases);结晶学, X线(Crystallography, X-Ray);疾病模型, 动物(Disease Models, Animal);药物发现(Drug Discovery);女(雌)性(Female);人类(Humans);炎症(Inflammation);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 转基因(Mice, Transgenic);模型, 化学(Models, Chemical);模型, 分子(Models, Molecular);分子结构(Molecular Structure);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白质结构, 三级(Protein Structure, Tertiary);喹啉类(Quinolines);大鼠, 近交Lew(Rats, Inbred Lew);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm501624r
PMID
25469863
发布时间
2018-07-26
- 浏览55
Journal of medicinal chemistry
480-511页
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