换一批Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.
第一作者：
Michelle,Cicchini
第一单位：
a Rutgers Cancer Institute of New Jersey ; New Brunswick , NJ USA.
作者：
关键词
8-O-dG, 8-oxo-7, 8-dihydroguanineATG, autophagy-relatedBECN1, Beclin 1, autophagy-relatedBSA, bovine serum albuminBeclin 1CASP3, caspase 3CD24, cluster of differentiation 24DAPI, 4′, 6-diamidino-2-phenylindoleDFS, disease-free survivalDMEM, Dulbecco's modified Eagle's mediumE, 17b-estradiolEGF, epidermal growth factorEGFP, enhanced green fluorescent proteinEGFR/ERBB1, epidermal growth factor receptorEM, electron microscopyEMT, epithelial-to-mesenchymal transitionERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2ESR1, estrogen receptor 1FACS, fluorescence activated cell sortingFGF2/bFGF, fibroblast growth factor 2 (basic)GSEA, gene set enrichment analysisH&E, hematoxylin &, eosinHR, hormone receptorIF, immunofluorescenceIHC, immunohistochemistryIL, interleukinITGB1/CD29, Integrin, beta 1 (fibronectin receptor beta polypeptide, antigen CD29 includes MDF2, MSK12)ITGB3/CD61, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)KRT, keratinKeratin 6LIN?, lineage negative (CD31? CD45? LY76?)LY76/TER119, lymphocyte antigen 76MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 betaMEC, mammary epithelial cellMEGM, mammary epithelial growth mediumMGs, mammary glandsMKI67, marker of proliferation Ki-67MMTV, mouse mammary tumor virusMaPC, mammary progenitor cellMaSC, mammary stem cellNFKBNFKB/NFkB, nuclear factor of kappa light polypeptide gene enhancer in B-cellsPBS, phosphate-buffered salinePECAM1/CD31, platelet/endothelial cell adhesion molecule 1PGR, progesterone receptorPI, propidium iodidePTPRC/CD45, protein tyrosine phosphatase, receptor type, CRELA/P65, v-rel avian reticuloendotheliosis viral oncogene homolog aROS, reactive oxygen speciesSD, standard deviationSNPs, single nucleotide polymorphismsSQSTM1/p62, sequestosome1TEBs, terminal end budsTNBCTNBCs, triple-negative breast cancersTNF, tumor necrosis factorTNF11TNFRSF11ATNFRSF11A/TNR11/RANK, tumor necrosis factor receptor superfamily, member 11a, NFKB activatorTNFSF11TNFSF11/TNF11/RANKL, tumor necrosis factor (ligand) superfamily, member 11TNR11TP53 (TRP53 in mice), tumor protein p53 (transformation related protein 53 in mice)WNT1WNT1, wingless-Type MMTV integration site family, member 1basal-like breast canceriMMECs, immortalized mouse mammary epithelial cellsp-KRT8/p-K8, phosphorylated Keratin 8parity
医学主题词
等位基因(Alleles);动物(Animals);细胞凋亡(Apoptosis);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);自噬(Autophagy);乳腺肿瘤(Breast Neoplasms);细胞增殖(Cell Proliferation);上皮细胞(Epithelial Cells);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);杂合子(Heterozygote);人类(Humans);乳房肿瘤, 动物(Mammary Neoplasms, Animal);乳房肿瘤, 实验性(Mammary Neoplasms, Experimental);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 裸(Mice, Nude);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);信号传导(Signal Transduction);干细胞(Stem Cells);Wnt1蛋白质(Wnt1 Protein)
DOI
10.4161/auto.34398
PMID
25483966
发布时间
2018-11-13
- 浏览161
Autophagy
2036-52页
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