换一批High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation.
第一作者：
Claudia T,Mendler
第一单位：
a Munich Center for Integrated Protein Science (CIPS-M) and Lehrstuhl für Biologische Chemie ; Technische Universität München ; Freising-Weihenstephan , Germany.
作者：
关键词
ABD, albumin binding domainCD20CDC, complement-dependent cytotoxicityCDR, complementarity-determining regionCLL, chronic lymphocytic leukemiaDMEM, Dulbecco's modified Eagle mediumEPR, enhanced permeability and retention effectFACS, fluorescence-activated cell sortingFBS, fetal bovine serumFab, antigen-binding fragmentFcRn, neonatal Fc receptorHER2HER2, human epidermal growth factor receptor 2ID, injected doseIDA, iminodiacetic acidIg, immunoglobulinMIP, maximum intensity projectionNHL, non-Hodgkin lymphomaPEGylationPET, positron emission tomographyPK, pharmacokineticsRIT, radioimmuno therapySEC, size exclusion chromatographySPECT, single photon emission computed tomographyTLC, thin layer chromatographyantibody fragmentmAb, monoclonal antibodyp.i., post injectionplasma half-lifeprotein tracerscFv, single-chain variable antibody fragment
医学主题词
动物(Animals);抗体, 肿瘤(Antibodies, Neoplasm);抗原, CD20(Antigens, CD20);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);人类(Humans);免疫球蛋白Fab片段(Immunoglobulin Fab Fragments);碘同位素(Iodine Isotopes);同位素标记(Isotope Labeling);小鼠(Mice);肿瘤移植(Neoplasm Transplantation);肿瘤, 实验性(Neoplasms, Experimental);正电子发射断层显像术(Positron-Emission Tomography)
DOI
10.4161/19420862.2014.985522
PMID
25484039
发布时间
2018-11-13
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