换一批CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas.
第一作者：
Michael D,Oberst
第一单位：
a MedImmune LLC ; Gaithersburg , MD USA.
作者：
关键词
AMG 211BiTE?, bi-specific T cell engagerCD3CEACEA, carcinoembryonic antigenCEACAM5, CEA-related cell adhesion molecule family member 5DHFR, dihydrofolate reductaseEC50, half maximal effective concentrationFFPE, formaldehye fixed paraffin embeddedIV, intravenousMEDI-565MEDI-565, bispecific single-chain antibody specific for CEA and human CD3MT111SC, subcutaneousSEM, standard error of the meanT cellsTMA, tissue microarraybispecific antibodyperipheral blood mononuclear cells, PBMCscFv, single chain variable fragment
医学主题词
腺癌(Adenocarcinoma);动物(Animals);抗体, 双特异性(Antibodies, Bispecific);CHO细胞(CHO Cells);癌胚抗原(Carcinoembryonic Antigen);细胞系, 肿瘤(Cell Line, Tumor);细胞, 培养的(Cells, Cultured);结直肠肿瘤(Colorectal Neoplasms);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);细胞毒性, 免疫(Cytotoxicity, Immunologic);女(雌)性(Female);HT29细胞(HT29 Cells);人类(Humans);淋巴细胞活化(Lymphocyte Activation);男(雄)性(Male);小鼠, SCID(Mice, SCID);突变(Mutation);肿瘤(Neoplasms);蛋白质结合(Protein Binding);T淋巴细胞(T-Lymphocytes);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.4161/19420862.2014.975660
PMID
25484061
发布时间
2022-04-08
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