换一批
换一批The cellular form of the prion protein guides the differentiation of human embryonic stem cells into neuron-, oligodendrocyte-, and astrocyte-committed lineages.
作者：
关键词
CNTF, ciliary neurotrophic factorEBs, embryoid bodiesEFG, epidermal growth factorESCs, embryonic stem cellsGFAP, glial fibrillary acidic proteinGRM, glial restrictive mediumLenti-ShPrPC, lentiviral vector expressing short hairpin RNA against PrPCLenti-ShScram, lentiviral vector expressing scrambled shRNALenti-TetR, lentiviral vector expressing tetracycline repressorMEF-CM, mouse embryonic feeder-conditioned mediumMEFs, mouse embryonic fibroblastsNDM, neuronal differentiation mediumNIM, neural induction mediumNPM, neural proliferation mediumOlig1, a marker of oligodendrocyte-committed lineagesPrPC, normal, cellular isoform of the prion proteinRA, retinoic acidSyn, synapsin ITH, tyrosine hydroxylaseTet, tetracyclineTetR, tetracycline repressorbFGF, basic fibroblast growth factorhES+TetR+ShPrPC, hESCs transfected with Lenti-TetR and Lenti-ShPrPChES+TetR+ShScram, hESCs transfected with Lenti-TetR and Lenti-ShScramhESCs, human ESCshuman embryonic stem cellsneural progenitor cellsneuron-committed lineagesprion proteinstem cell differentiation
主题词
星形细胞(Astrocytes);胚胎干细胞(Embryonic Stem Cells);基因沉默(Gene Silencing);人类(Humans);神经发生(Neurogenesis);神经元(Neurons);少突神经胶质(Oligodendroglia);PrPC蛋白质类(PrPC Proteins)
DOI
10.4161/pri.32079
PMID
25486050
发布时间
2022-03-16
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